Gamma-aminobutyric acid transporters

Liu, Q. R., Lopdz-Corcuera, B., Mandiyan, S Nelson, H and Nelson, N. (1993) Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain. J. Biol. Chem. 268,2106-2112. 

Golovanevsky, V. and Kanner, B. I. (1999) The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue. J. Biol. Chem. 274,23020-23026. 

White, H. S., Sarup, A., Bolvig, T., et al. (2002) Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-l,2-benzisoxazole and its N-alkylated analogs. J. Pharmacol. Exp. Ther. 302, 636-644. 

Clark, J. A. (1997) Analysis of the transmembrane topology and membrane assembly of the GAT-1 gamma-aminobutyric acid transporter. J. Biol. Chem. 272,14695-14704. 

Tamura, S., Nelson, H., Tamura, A., and Nelson, N. (1995) Short external loops as potential substrate binding site of gamma-aminobutyric acid transporters. J. Biol. Chem. 270, 28712-28715. 

Zomot E, Kanner BI. The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV. J. Biol. Chem. 2354 278 42950-42958. 

Corey JL, Davidson N, Lester HA, Brecha N, Quick MW (1994) Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. J Biol Chem 269 14759-14767. 

McGeer PL, Hattori T, McGeer EG (1975) Chemical and autoradio-graphic analysis of gamma-aminobutyric acid transport in Purkinje cells of the cerebellum. Exp. Neurol 47, 26-41. 

Martin DL, Shain W (1979) High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells. J Biol Chem 254(15) 7076-7084... 

Twaites, D. T., Basterfield, L., McCleave, P. M. J., Carter, S. M., and Simmons, N. L., Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers, Brit.J. Pharmacol. 2000, 129, 457-464. 

Larsson, O. M., Griffiths, R., Allen, I. C., and Schousboe, A. (1986) Mutual inhibition kinetic analysis of gamma-aminobutyric acid, taurine and beta-alanine high-affinity transport into neurons, and astrocytes evidence for similarity between the taurine and beta-ala-nine carriers in both cell types. J. Neurochem. 47,426 132. 

Schousboe, A., Larsson, O. M., Wood, J. D., and Krogsgaard-Larsen, P. (1983) Transport and metabolism of gamma-aminobutyric acid in neurons and glia implications for epilepsy. Epilepsia. 24, 531-538. 

Engineered Zn2+ switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents. J. Biol. Chem. 276,40476 10485. 

Susdak PD, Schwartz RD, Scolnick P, et al Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci U S A 83 4071-4075, 1986... 

Jin H, Wu H, Osterhaus G, Wei J, Davis K, Sha D, Floor E, Hsu CC, Kopke RD, Wu JY (2003) Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles. Proc Natl Acad Sci USA 100 4293 1298. 

Kish PE, Fischer-Bovenkerk C, Ueda T (1989) Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles. Proc Natl Acad Sci USA 86 3877-3881. 

Selectively blocks reuptake ot gamma-aminobutyric acid (GABA) by presynaptic and glial GABA transporters... 

Ethanol is a central nervous system (CNS) depressant that initially and selectively depresses some of the most active portions of the brain (reticular activity system and cortex). The mechanism of action most likely involves interference with ion transport at the axonal cell membrane rather than at the synapse, similar to the action of other anesthetic agents. Ethanol can bind directly to the gamma-aminobutyric acid (GABA) receptor in the CNS and cause... 

Bernstein EM, Quick MW (1999) Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA. J Biol Chem 274 889-895. 

Maestrini E, Lai C, Marlow A, Matthews N, Wallace S, Bailey A, Cook EH, Weeks DE, Monaco AP (1999) Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. Am J Med Genet 88 492 96. 

Gamma-aminobutyric acid (GABA), glutamic acid decarboxylase (GAD) and the GABA-transporters in Purkinje cells... 

I. Mechanism of toxicity. The growth of C tetani in a wound under anaerobic conditions produces the toxin tetanospasmin. The toxin enters the myoneural junction of alpha motor neurons and travels via retrograde axonal transport to the synapse. There it biocks the release of the presynaptic inhibitory neurotransmitters gamma-aminobutyric acid (GABA) and glycine, causing intense muscular spasms. 

---