Glutamate receptors inhibition

Swartz, K. J., Merritt, A., Bean, B. P., and Lovinger, D. M. (1993) Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature 361,165-168. 

Airas, J. M., Betz, H., and El Far, O. (2001) PKC phosphorylation of a conserved serine residue in the C-terminus of group HI metabotropic glutamate receptors inhibits calmodulin binding. FEBS Lett. 494, 60-63. 

Sutton KG, McRory JE, Guthrie H, Murphy TH, Snutch TP (1999) P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-lA. Nature 401 800-4 Swartz KJ (1993) Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons disruption of G protein-mediated inhibition. Neuron 11 305-20 Swartz KJ, Merritt A, Bean BP, Lovinger DM (1993) Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature 361 165-8 Takahashi SX, Miriyala J, Colecraft HM (2004) Membrane-associated guanylate kinase-like properties of beta-subunits required for modulation of voltage-dependent Ca2+ channels. Proc Natl Acad Sd US A 101 7193-8... 

Lombardi G, Alesiani M, Leonardi P et al (1993) Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum. Br J Pharmacol 110 407-12... 

Manzoni O, Bockaert J (1995) Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus. Eur J Neurosci 7 2518-23 Marchi M, Risso F, Viola C et al (2002) Direct evidence that release-stimulating a7 nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals. J Neurochem 80 1071-8... 

Goudet C, Chapuy E, AUoui A, Acher F, Pin JP, Eschalier A (2008) Group 111 metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 137 112-124... 

Kim SJ, Calejesan AA, Zhuo M (2002) Activation of brainstem metabotropic glutamate receptors inhibits spinal nociception in adult rats. Pharmacol Biochem Behav 73 429-437 Kirouac GJ, Li S, Mabrouk G (2004) GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus. J Comp Neurol 469 170-184... 

Stefani A, Pisani A, Mercuri NB, Bernard G, Calabresi P (1994) Activation of metabotropic glutamate receptors inhibits calcium currents and GABA-mediated synaptic potentials in striatal neurons. J Neurosci 74 6734-6743. 

Galante M, Diana MA (2004) Group 1 metabotropic glutamate receptors inhibit GABA release at interneuron-Purkinje cell synapses through endocannabinoid production. J Neurosci 24 4865-4874... 

Bradley SR, Marino MJ, Wittmann M et al (2000) Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia Nigra pars reticulata. J Neurosci 20 3085-3094... 

Altered synaptic properties Numerous changes in the properties of inhibitory (GABAergic) and excitatory (glutamatergic) synapses have been reported. While the simple adage of an imbalance between inhibitory and excitatory neurotransmission in epilepsy is not generally applicable, some forms of inhibition are lost or impaired in epilepsy. Likewise, an increased function of glutamate receptors has been demonstrated in some brain areas. 

Tessari, M., Pilla, M., Andreoli, M., Hutcheson, D.M., Heidbreder, C.A. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur. J. Pharmacol. 19 121, 2004. 

---