Prostatic atrophy

Bethel GR, Faith D, Li X, et al. Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma association with gleason score and chromosome 8p deletion. Cancer Res. 2006 66 10683. 

Androgens act via the AR and play an important role in the development and differentiation of the male sexual organ. Furthermore, they are involved in several diseases, the most important being partial and complete androgen insensitivity syndrome (AIS formerly known as the testicular feminization syndrome), spinal and bulbar muscle atrophy (SBMA Kennedy s disease), and the neoplastic transformation of the prostate. The two natural occurring androgens are testosterone (T) and the... 

De Marzo, A, N Yasutomo, and WG Nelson. 2007. Inflammation, atrophy, and prostate carcinogenesis. Urol Oncol 25 398-400. 

Weight gain, acne, hirsutisrrt dyslipide-mia, hepatic consequences, gynecomastia, priapism, prostate disorders, testicular atrophy, sleep apnea, and skin reactions with patches... 

Genitourinary Atrophy of the vagina due to decreased estrogen Prostatic hypertrophy due to androgenic hormonal changes Age-related changes may predispose to incontinence... 

Estrogens are most commonly used as a component of combination contraceptives or as hormone replacement therapy in postmenopausal women. Benefits in postmenopausal women include relief of moderate to severe vasomotor symptoms and decreased risk of osteoporosis. Hormone replacement therapy also may be used in vaginal and vulvar atrophy and in hypoestrogenism caused by hypogonadism, castration, or primary ovarian failure. Less commonly, select breast or prostate cancer... 

Saw palmetto is known to have diuretic, urinary antiseptic, endocrinological, and anabolic properties. Traditionally, it is used for chronic or subacute cystitis, catarrh of the genitourinary tract, testicular atrophy, sex hormone disorders, and specifically for prostatic enlargement. 

Other additional studies or pertinent information that lend support to this MRL Other studies have established that testicular toxicity is a critical effect of DEHP. It is well documented that oral exposure to DEHP in adult rats and mice caused decreased weights of the testes, prostate, seminal vesicles, and epididymis, atrophy and degeneration of the seminiferous tubules, and/or altered sperm measures and reduced fertility (postal et al. 1988 Ganning et al. 1991 Gray and Butterworth 1980 Gray and Gangolli 1986 Kluwe et al. 1982a Lamb et al. 1987 Oishi 1986, 1994 Parmar et al. 1987, 1995 Price et al. 

The dithiazolylium salts (228), besides being insect chemosterilants, cause atrophy of the prostate gland and seminal vesicles in male rats, as well as inhibiting ovulation and interrupting pregnancy in females. The results of a detailed study have recently been... 

Androgens have been considered to play a crucial role in the development and progression of prostate cancer, since men castrated before puberty do not develop prostate cancer (L10). Testosterone is the major steroid hormone that maintains prostate growth, function, and size. Treatment of stage D prostate cancer includes withdrawal of testosterone by surgical or medical castration, which causes atrophy of androgen-dependent cancer cells. Most treatments involve Zoladex (goserelin)... 

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