Ovulation, inhibition

Long-acting progestins act primarily as ovulation inhibitors. An important secondary component is their effect on the cervical mucus and endometrium, achieved at circulating blood dmg levels below those required for ovulation inhibition (40). 

Ovulation inhibition effect. Petroleum ether extract of the aerial parts, administered orally to rats, produced weak activity ... 

Ovulation inhibition effect. Water, ethanol (95%), and petroleum ether extracts of the seed, administered orally to rabbits at a dose of 100 mg/kg, were inactive . Pheromone effect (sex attractant). Water extract of the root was active on Costelytra zeahmdicaP. ... 

Cunningham GR, Goldzieher JW, de la Pena A, Oliver M. The mechanism of ovulation inhibition by triamcinolone acetonide. J Clin Endocrinol Metab 1978 46(1) 8-14. 

Coutinho EM, Silva AR, Carreira C, Barbosa I. Ovulation inhibition following vaginal administration of pills containing norethindrone and mestranol. Contraception 1984 29(2) 197-202. 

Killick, S. 2002. Complete and robust ovulation inhibition with NuvaRing. Eur J Contracept Reprod Health Care 7 13. 

The ovulation-inhibiting component of many oral contraceptive pills is a compound known as ethynyloestradiol, and this compound too is made by an alkynyllithium addition to the female sex hormone... 

Ovulation-inhibiting activities of progestagens in the rabbit (oral)... 

Inhibiting implantation through a drug-induced altered endometrium is another possible means of preventing pregnancy. In fact, if contraceptives do Inhibit luteal function > > then the latter mechanism may be more Important than ovulation inhibition since the indirect criteria for determining ovulation are luteal dependent. It also appears urinary excretion of LU and pregnanediol may not be reliable indicators of ovulation. 

The 3,6-dimethylderivative (7) is weakly active as a progestin. The synthesis of the interesting 11-oxaprogesterone (8) was reported. The product has approximately twice the ovulation inhibiting activity of progesterone and l/6th its potency as measured by the Clauberg test. ... 

---