Post mortem analysis

Jaramillo A, Gongora-Rivera F, Labreuche J, Hauw JJ, Amarenco R Predictors for malignant middle cerebral artery infarctions a post-mortem analysis. Neurology 2006 66(6) 815-820. 

Opens specified file and redirects PRINT and OUTPUT text to the file for post-mortem analysis. ENDFILE or SAVE will close the file. 

A 10-year-old boy was hospitalized with serious bums during the next 2.5 days his bums were treated by applying 7.5 L of an antiseptic solution containing 2% phenol his urine became dark, respiration became labored, he fell into a coma, and died. Post mortem analysis of urine showed 200 mg/L of conjugated phenol (Cronin and Brauer 1949). 

Comprehensive toxicity studies are carried out by animal testing in order to ascertain whether the product exhibits any short-term or long-term toxicity. Acute toxicity is usually assessed by administration of a single high dose of the test drug to rodents. Both rats and mice (male and female) are usually employed. The test material is administered by two means, one of which should represent the proposed therapeutic method of administration. The animals are then monitored for 7-14 days, with all fatalities undergoing extensive post-mortem analysis. 

In this chapter, we have aimed to present illustrative examples - the success stories. Some of these successes undoubtedly arise by serendipity, essentially by post-mortem analysis of observed crystal structures. Others are indeed the result of inspired design. The continuing challenge for crystal engineers is to tip the balance away from the fortuitous towards the true manipulation of the three-dimensional architecture of molecular crystals. 

The limitation of the ex situ approach is that the composition and structure of the catalyst surface are not investigated under reaction conditions. This limitation prevents the post-mortem analysis of the catalyst under UHV to determine an assessment of the surface restructuring, intermediate species, segregation of specific components, etc., that are characteristic of reaction conditions. 

Additions of Ti to A1 suppress the formation of A14C3 at the Al/SiC interface and lead to contact angles close to 20° at 1150°C. Post mortem analysis reveals the formation of a reaction product layer consisting mainly of TiC and TiSi2 phases (Sobczak et al. 1998). 

Post-mortem analysis has also been carried out. Microstructural observation at the cross-section showed that significant grain growth, recrystallization and plastic deformation due to thermal stress occurred. Surface analysis indicated that the deuterium concentration was less than 0.1%... 

One of the important areas of catalyst characterization is to provide information on the bulk and surface properties in relation to the preparation methods, including precursors, calcined, prereduced, or otherwise pretreated catalysts. Other, no less important areas pertain to catalysts in their active working state and to post-mortem analysis of gradually or suddenly deactivated catalysts. There is no greater incentive for a rapid catalyst characterization than a 1,000-ton reactor making a 400,000/day product going down due to a catastrophic catalyst deactivation. 

Garcia, C., Bravo, M. d. C., Lagos, M. and Lagos, N. Paralytic shellfish poisoning post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords. Toxicon, 43, 149-158 (2004). 

Eight calves had been derived from differentiated cells of a single adult cow, five from cumulus cells and three from oviductal cells out of 10 embryos transfened to suiTOgate cows (80% success). All calves were visibly normal, but four died at or soon after bh th from envu onmental causes and post-mortem analysis revealed no abnormality. These results show that bovine cumulus and oviductal epithelial cells of the adult have tire genetic content to duect the development of newborn calves. 

A young man died from the combined cardiovascular and respiratory depressant effects of hydromorphone and alcohol. He fell asleep, the serious nature of which was not recognised by those around him. Post-mortem analysis revealed alcohol and hydromorphone concentrations of 90 mg% and 100 nanograms/mL, respectively, neither of which is particularly excessive. A study in 9 healthy subjects found that pre-treatment with hydromorphone 1 or 2 mg did not significantly affect the subject-rated effects of alcohol 0.5 or 1 g/kg. However, hydromorphone enWiced the sedative scores of alcohol on the adjective rating scale." See also, controlled-release opioids, below. 

Four patients died after taking moclobemide and ecstasy (MDMA, methylenedioxymethamfetamine). The clinical evidence is limited, but in each case the forensic pathologist concluded that the cause of death was the combined use of these drugs. It was suggested that what happened is consistent with the serotonin syndrome, although the evidence is fairly slim. Two patients had taken maximum therapeutic doses and two moderate overdoses of moclobemide. Note that moclobemide had not been prescribed to any of them. Post-mortem analysis also found the presence of dextromethorphan in one patient, which was thought to have contributed, see also MAOIs or RIMAs -i- Dextromethorphan , p.ll34. 

Another major hazard in high-integrity systems, tasks terminating silently, has been addressed in Ada 2005 with a new mechanism for setting user-defined handlers which are executed when tasks are about to terminate. These procedures are invoked when tasks are about to terminate (either normally, as a result of an unhandled exception, or due to abort), allowing controlled responses at run time and also logging these events for post-mortem analysis. 

Galibiati et al. [147] observed gradually increased hydrogen crossover and short circuit current during continuous operation at 400 mA cm for 6000 h at 180 °C, which is an indication of membrane-related degradation. Post mortem analysis of membrane-electrode assemblies that had been operated at constant load of 200 mA cm at 150 °C, revealed considerable membrane thinning starting after about... 

M. Elisabeth Pate-Comell, Learning from the Piper Alpha accident a post-mortem analysis of technical and organisational factors. Risk Analysis 13 (2) (1993). 

Accordingly, each project or a sampling of an organization s projects, ranging from the successful to the mediocre or failed projects, should be immediately followed by a post-mortem analysis to determine what can be learned for the benefit of near-future projects. Lessons learned should be documented and widely shared within the organization. Two important components of this post-project review are input from the client, owner or customer and a meeting of the project team. The client, owner, or customer interaction should precede the team meeting so that the team has the benefit of input form those who were served. 

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