Coatings polysaccharide

Examples with other Pirkle-type CSPs have also been described [139, 140]. In relation to polysaccharides coated onto silica gel, they have shown long-term stability in this operation mode [141, 142], and thus are also potentially good chiral selectors for preparative SFC [21]. In that context, the separation of racemic gliben-clamide analogues (7, Fig. 1-3) on cellulose- and amylose-derived CSPs was described [143]. 

Some microbes are able to decrease the permeability of their membranes to prevent toxic metals from entering. If the toxic metals are not able to physically enter the cell, they will not be able to affect vital metal-sensitive structures, such as proteins. One way to prevent heavy metals from entering is by decreasing the production of membrane channel proteins.18 It is also possible for the metal-binding sites in the membrane and periplasm to be saturated with nontoxic metals.37 A third possibility is the formation of an extracellular polysaccharide coat, which binds and prevents metals from reaching the surface of the cell.24,38... 

Lenart, A. and Dabrowska, R. 1997. Osmotic dehydration of apples with polysaccharide coatings. 

Sata T (1990) Polysaccharide coated liposomes, Ph D Thesis, University of Nagasaki... 

Sunamoto, J., and Iwamoto, K. Protein-coated and polysaccharide-coated liposomes as drug carriers. CRC Crit. Rev. Ther. Drug Carrier Sys. 2 117—136, 1987. 

Okamoto, Y. Kawashima, M., and Hatada, K. (1984) Useful chiral packing materials for high-performance liquid chromatographic resolution of enantiomers phenylcarbamates of polysaccharides coated on silica gel,... 

The mechanisms that prevent nonspecific adsorption are still under debate, and since there is no generally accepted, standardized testing method for nonspecific adsorption, results are often hard to compare. Work from Whitesides and coworkers suggested an important role of hydrogen bond acceptors [159, 177]. Many reports on sufficient suppression of nonspecific adsorption by polysaccharide coatings... 

Most of the nucleic acid model compound prepared so far are water insoluble however, when the analogs are water soluble, they may not permeate into the hydrophobic cell membranes. Recently, an improved drug delivery system for water soluble drugs using polysaccharide-coated liposomes [68] was developed. 

Several pharmaceutical activities of nucleic acid analogs such as poly(VAd) have been studied in vitro and in cell-free systems [19]. It was expected that the present polymers would be effectively transferred into phagocytes by encapsulating in polysaccharide-coated liposomes and would show increased pharmaceutical activities similar to poly(maleic acid-a/l-2-cyclohexyl-l, 3-dioxap-5-ene) (MA-CDA) [68]. The activation of human neutrophils by poly(VAd) was evaluated by monitoring the in vitro superoxide anion production from activated human neutrophils. Shown in Table 15 is the superoxide liberated from human neutrophils (1 x 106 cells/ml) activated by poly(VAd) (0.5 mg/ml) as a function of time. Poly(VAd) encapsulated in mannan derivative-coated liposomes showed a... 

Poly(VAd) in the polysaccharide-coated liposomes activated mouse peritoneal macrophages more effectively than free poly(VAd) and the % increase in 02 maximizes at 2 h after administration (Fig. 20). These results show that poly(VAd), which is a typical synthetic analog of nucleic acids [19], modulates immune responses similar to native polynucleotides [70]. Poly(VAd-eo-MAn) in polysaccharide-coated liposome activated mouse peritoneal macrophages more effectively than free poly(VAd-eo-MAn). The percent increase in O2- production at... 

A comparative study on the release of 5-FU and its derivatives from polysaccharide-coated microspheres MS [CM] was carried out in physiological saline at 37 °C. Data indicated that the 5-FU-release rate decreased in the order ffee-5-FU>carboxymethyl type 5-FU>ester type 5-FU. The results revealed that the coating layers on the microspheres were effective barriers to 5-FU release. 

Lemarchand, C., Gref, R., Passirani, C., Garcion, E., Petri, B., Muller, R., Costantini, D., and Couvreur, P. (2006), Influence of polysaccharide coating on the interactions of nanoparticles with biological systems, Biomaterials, 27(1), 108-118. 

Iwamoto, K., Kato, T., Kawahara, M., Koyama, N., Watanabe, S., Miyake, Y., and Sunamoto, J. (1991), Polysaccharide-coated oil droplets in oil-in-water emulsions as targetable carriers for lipophilic drugs, J. Pharm. Sci., 80, 219-224. 

Polysaccharide-coated CSP are prepared by coating of their benzoate or carbamate derivatives on substrate from a solution with the following evaporation of the solvent. These phases can be used under RP conditions with aqueous eluents or in normal-phase conditions with limited number of solvents to avoid dissolution of the coated layer [80, 81]. 

Y. Okamoto, M. Kawashima, and K. Hatada, Chromatographic resolution. 7. Useful chiral packing materials for high-performance hquid chromatographic resolution of enantiomers Phenylcarbamates of polysaccharides coated on sihca gel, J. Am. Chem. Soc. 106 (1984), 5357-5359. 

Venkatesan N, Vyas SP (2000) Polysaccharide coated liposomes for oral immimization development and characterization. Int J Pharm 203 169-177... 

Sebti, I. and Coma, V. 2002. Active edible polysaccharide coating and interactions between solution coating compounds. Carbohydrate Polymers 49 139-144. 

Keuren J F, Wielders S J, Willems G M (2003). Thrombogenicity of polysaccharide-coated surfaces. Biomaterials. 24 1917-1924. 

Uthaman, S., et al. Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy. BioMed Research International... 

Polysaccharide-coated liposomes were prepared by essentially the same procedure as that adopted for the conventional liposomes. ... 

Preparation of polysaccharide-coated liposome encapsulating [ CoQio... 

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