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First in class

Rimonabant is the first-in class CB1 receptor antagonist, which has recently reached the market in Europe (approval in the US is pending). The reduction of... [Pg.161]

Another important acid derived from the corresponding unsamrated acid family is the a-alkyl substituted acid (C). This compound is used in the synthesis of Aliskiren (the active ingredient of Tektuma ) which Novartis has recently been granted FDA approval as the first-in-class renin inhibitor for control of blood pressure. It is estimated that large volumes of this intermediate will be required in the future but the best ee reported so far for production of this intermediate is 95 % as shown in Figure 1.8. ... [Pg.6]

Debruyne F et al Abarelix for injectable suspension first-in-class gonadotropin-releasing hormone antagonist for prostate cancer. Future Oncol 2006 2 677. [PMID 17155895]... [Pg.851]

Jones CH, Petersen PJ. Tigecycline a review of pre-clinical and clinical studies of the first-in-class glycyl-cycline antibiotic. Drugs Today. 2005 41 637-659. [Pg.520]

First-in-class None or limited Low efficacy in the general Mild or Not an immediate Not an immediate Not an immediate... [Pg.34]

First-in-class withdrawn post-approval due to toxicity, or hitherto failed in clinical development None or limited alternatives High Serious morbidity or mortality Low Not an immediate consideration At least 5 years or more... [Pg.34]

Raltegravir (Isentress) The First-in-Class HIV-1 Integrase Inhibitor... [Pg.3]

Maraviroc (Selzentry) The First-in-Class CCR5 Antagonist for the... [Pg.17]

Bortezomib (Velcade) A First-in-Class Proteasome Inhibitor... [Pg.99]

Aliskiren (Tekturna), The First-in-Class Renin Inhibitor for... [Pg.141]

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See also in sourсe #XX -- [ Pg.31 ]



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Daklinza) The First-in-Class HCV NS5A Replication Complex Inhibitor

First-in-class drugs

Sofosbuvir (Sovaldi) The First-in-Class HCV NS5B Nucleotide Polymerase Inhibitor

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