Soluble synthetic polymers

Drobnik,J. and Rypaiek,F. Soluble Synthetic Polymers in Biological Systems. Vol. 57, pp. 1 — 50. 

Duncan, R. and Kopecek, J. Soluble Synthetic Polymers as Potential Drug Carriers. Vol. 57,... 

Drobnik, J. and Rypalek, F. Soluble Synthetic Polymers in Biological Systems. Vol. 57, pp. 1-50. Droscher, M. Solid State Extrusion of Semicrystalline Copolymers. Vol. 47, pp. 120-138. 

Synthetic Polymers. Synthetic polymers are versatile and offer promise for both targeting and extracellular-intracellular drug delivery. Of the many soluble synthetic polymers known, the poly(amino acids) [poly(L-lysine), poly(L-aspartic acid), and poly(glutamic acid)], poly(hydroxypropylmethacrylamide) copolymers (polyHPMA), and maleic anhydride copolymers have been investigated extensively, particularly in the treatment of cancers. A brief discussion of these materials is presented. 

R Duncan, M Bhakoo, PA Flanagan, D Sgouras. Evaluation of the biocompatibihty of soluble synthetic polymers designed as drug carriers. Proc Int Symp Controlled Release Bioact Mater 15 121-122, 1988. 

Duncan, R., and Kopecek, J. (1984) Soluble synthetic polymers as potential drug carriers. Adv. Polym. Sci. 57, 53-101. 

Molyneux P (1985) Water-soluble synthetic polymers properties and behaviour. CRC, Boca Raton, FL... 

Gel electrophoresis is widely used in the routine analysis and separation of many well-known biopolymers such as proteins or nucleic acids. Little has been reported concerning the use of this methodology for the analysis of synthetic polymers, undoubtedly since in many cases these polymers are not soluble in aqueous solution - a medium normally used for electrophoresis. Even for those water-soluble synthetic polymers, the broad molecular weight dispersities usually associated with traditional polymers generally preclude the use of electrophoretic methods. Dendrimers, however, especially those constructed using semi-controlled or controlled structure synthesis (Chapters 8 and 9), possess narrow molecular weight distribution and those that are sufficiently water solubile, usually are ideal analytes for electrophoretic methods. More specifically, poly(amidoamine) (PAMAM) and related dendrimers have been proven amendable to gel electrophoresis, as will be discussed in this chapter. 

Soluble synthetic polymers have been widely employed as versatile drug carrier systems. Polymer chemistry allows the development of tailor made conjugates in which target moi-... 

Thus one might expect flexible, water-soluble synthetic polymers with suitable side chains to show strong affinities for small molecules. In the course of 20 years we examined the binding ability of polyvinylpyrrolidone, polyvinylpyridine, polylysine, polyacrylamide, polyisopro-pylacrylamide, polyvinylimidazole, polyvinylmethyloxazolidinone,... 

P. Molyneux, Water-Soluble Synthetic Polymers Properties andBehavior, Vols. I and II, CRC Press, Boca Raton, Fla., 1982. 

Thus one might expect flexible, water-soluble synthetic polymers with suitable side chains to show affinities for small molecules. We have examined, over several decades, the binding ability of poly(vinylpyrrolidone), polyvinylpyridine, polylysine, polyacrylamide, poly(isopropylacrylamide), poly(vinylimidazole), poly(vinylmethyloxazolidi-none), poly(vinylmethyloxazolidinone-vinylimidazole), poly(vinylpyrrolidone-vinyli-midazole), poly(vinylpyrrolidone-vinyl alcohol), poly(vinylpyrrolidone-maleic anhydride), poly(vinylmethyloxazolidinone-maleic anhydride), and poly(2-methylami-noethyl methylacrylate-methacrylic acid). Other investigators have studied similar synthetic polymers [5-12], In our experience no water-soluble polymer binds small molecules with an avidity comparable to serum albumin. 

Flow FFF has been applied to a variety of species including proteins, water-soluble synthetic polymers, organic-soluble synthetic polymers, and various colloidal particles. The fractionation of proteins is illustrated in Figure 9.10. 

Soluble carriers include antibodies and soluble synthetic polymers such as poly(hydroxypropyl methacrylate), poly(lysine), poly(aspartic acid), polyvinylpyrrolidone), poly(N-vinyl-2-pyrrolidone-co-vinylamide) and poly (styrene co-maleic acid/anhydride). 

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