Design and Synthesis of Facially Amphiphilic Arylamide Polymers

6 Design and Synthesis of Facially Amphiphilic Arylamide Polymers 

Polymers based on two different repeated units, compound 3, can be synthesised via polycondensation of the diamine with isophthaloyl chloride. The diamine resulted 

By methodically changing the side chains and possibly the polymeric backbone, it should be feasible to adjust the antimicrobial selectivity and toxicity of the polymers in a method analogous to the production of AMP and P-oligomers [59]. 

The emergence of drug-resistant bacteria has compromised the usage of many conventional antibiotics, leading to heightened interest in a variety of AMP. While these peptides exhibit good antibiotic properties, their size, stability, tissue distribution and toxicity have hindered efforts to connect these capabilities. To address such issues, Choi and co-workers [61] established small (molecular mass 1,000 Da) arylamide foldamers that mimic AMP. 

Compound R MIC (pg/ml) HC5, (pg/ml) Selectivity (HC50/MIC) Relative hydrophobidty (logA ow)  

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