Polymers custom design

Sternberg, K., Petersen, S., Grabow, N., et al. Implant-associated local drug delivery systems based on biodegradable polymers customized designs for different medical apphca-tions. Biomed. Tech. (Berl) 58,417-427 (2013). doi 10.1515/bmt-2012-0049... 

These results open the exciting possibility of using degradable, tyrosine-derived polymers as "custom-designed" antigen delivery devices. On the other hand, our results indicate that the immunological properties of tyrosine-derived polymers will have to be carefully evaluated before such polymers can be considered for use as drug delivery systems or medical implants. 

STRUCTURAL CONSOLIDATION. Structural consolidation of the plaster layer is necessary for protection against mechanical stresses, including seismic activity and vibrations generated by buses that bring visitors to the Valley of the Queens. The use of injectable polymers is a viable solution. The most stable polymers must be used, and it may be necessary to custom design polymers for this purpose. The integrity of the plaster layer, before, during, and after treatment must be determined and monitored by ultrasonic, piezoelectric, or photoacoustic methods. This procedure and the use of polymers for paint layer protection will require extensive controlled experimentation, especially on the physicochemical nature of the various pig-... 

One of the earliest examples of a polymer imprinted with a phosphate derivative came from Turkewitsch et al., who constructed a MIP for the selective recognition of cAMP in aqueous media (Fig. 3) [117]. The custom-designed fimctional monomer 1 was used to target the nucleotide via both aryl stacking and electrostatic interactions between the positively-charged nitrogen and the phosphate diester anion (Fig. 4). Rather cleverly, this func-... 

Fig. 4 Functional monomer custom-designed for cAMP-imprinted polymer...

Future biomedical applications of polymers will certainly profit from the design of new biomimetic polymers, which allow a specific interaction with living cells and tissues. Recent developments in this field not only demonstrate the advantages of these custom-designed polymers, but also highlight the still-existing limitations, like the difficulty to achieve cell selectivity or unspecific interaaions with biological fluids. Nevertheless, biomimetic polymers are already used in many clinical applications and can therefore be considered as one of the most important fields of current medical advances. 

Screen packs downstream of extruders Custom designed for each polymer. 

Processing of polymers for biomedical applications draws on the established plastic processing technologies with added clinically clean environments, and special steps to minimize degradation. They are usually smaller scale equipment than those used in commercial plastic manufacturing. There are also numerous methods developed to process small amounts of polymer and to fabricate custom designed parts. 

SynthGSiS StratGgy. Polymer chemistry offers the possibility to prepare glycopolymers with custom-designed properties since several groups with specific properties can be easily introduced along the pol5uner chain, as shown in the scheme ... 

The high cost, low production, and vulnerability to infection of both biological-based dermal matrices and composite cultured skins have created interest in synthetic polymer technology. These fiscal and supply arguments are not the only impetus for this exploration, as synthetic polymers have the added advantage of customized design to enable properties such as molecular elution or fluid absorption to effect better wound healing. 

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