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Poly D,L lactide

FIGURE 134 Moisture uptake profiles as a function of relative humidity for a number of amorphous systems including polymers (PVP, HPMCAS, a PLA, X), amorphous indomethacin (IMC, ) and a 50% IMC-PVP amorphous mixture ( ) [42d, 46]. MD simulations for similar systems at selected water compositions are discussed in this chapter. The solid line represents the predicted moisture uptake profile for PLA from a recent MD simulation [12b], The structure shown adjacent to the sohd hne is the monomer unit within PLA. [Pg.344]

Polymer—polymer iacompatibiHty encapsulation processes can be carried out ia aqueous or nonaqueous media, but thus far have primarily been carried out ia organic media. Core materials encapsulated tend to be polar soHds with a finite degree of water solubiHty. EthylceUulose historically has been the sheU material used. Biodegradable sheU materials such as poly(D,L-lactide) and lactide—glycoHde copolymers have received much attention. In these latter cases, the object has been to produce biodegradable capsules that carry proteias or polypeptides. Such capsules tend to be below 100 p.m ia diameter and are for oral or parenteral administration (9). [Pg.319]

Bissery, M. C., Valeriote, F., and Thies, C., Fate and effect of CCNU-loaded microspheres made of poly(D,L) lactide (PLA) or poly B-hydroxybutyrate (PHB) in mice, Proc. Int. Symp. Control. Rel. Bioact. Mater.. 12. 181, 1985. [Pg.38]

N Ammoury, H Fessi, JP Devissaguet, M Allix, M Plotkine, RG Boulu. Effect on cerebral blood flow of orally administered indomethacin-loaded poly (isobutylcyanoacrylate) and poly(d,l-lactide) nanocapsules. J Pharm Pharmacol 42 558-561, 1990. [Pg.288]

N Ammoury, H Fessi, JP Devissaguet, M Du-brasquet, S Benita. Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(-isobutyl-cyanoacrylate) nanocapsules in rats. Pharm Res 8 101-105, 1991. [Pg.288]

Free radical polymerization combined with anionic ring polymerization was employed for the synthesis of poly(N-vinylpyrrolidone)-fr-poly(D,L-lactide), PVP-fr-PDLLA, as shown in Scheme 49 [121]. The free radical polymerization of VP was conducted using 2,2/-azobis[2-methyl-M-(2-hydroxyethyl)propionamide] as the initiator, isopropyl alcohol and 2-... [Pg.65]

Lemoine D, Francois C, Kedzierewicz F et al (1996) Stability study of nanoparticles of poly (e-caprolactone), poly(D, L-lactide) and poly(D, L-lactide-co-glycolide). Biomaterials 17 2191-2197... [Pg.57]

Panyam J, Dali MM, Sahoo SK et al (2003) Polymer degradation and in vitro release of a model protein from poly(D, L-lactide-co-glycolide) nano- and microparticles. J Control Release 92 173-187... [Pg.60]

Waeckerle-Men Y, Allmen EU, Gander B et al (2006) Encapsulation of proteins and peptides into biodegradable poly(D, L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine 24 1847-1857... [Pg.62]

Singh, M., A. Singh, G.P. Talwar, Controlled Delivery of Diphtheria Toxoid Using Biodegradable Poly(D, L-Lactide) Microcapsules, Pharmaceutical Research. 8, 958, 1991. [Pg.13]

Panyam, J., Sahoo, S.K., Prabha, S., Bargar, T., Labhasetwar, V., Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(D,L-lactide-co-glycolide) nanoparticles. Int J Pharm 262, 1-11 (2003). [Pg.660]

Yang DJ, Kuang LR, Li C, Kann Z, Wallace S (1994) Computed tomographic hver enhancement with poly(d,l-lactide)-microencapsulated contrast media. Invest Radiol 29 (Suppl 2) ... [Pg.197]

Gautier S, D Aloia V, Halleux O, Mazza M, Lecomte P, Jerome R (2003) Amphiphilic copolymers of e-caprolactone and y-substituted-e-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles. J Biomater Sci Polym Ed 114 63-85... [Pg.215]

Earlier, ROP of glycolide and D,L-lactide through precipitation was carried out in nontoxic supercritical CO2 in the presence of SnOct2as initiator and copoly(ester) poly(D,L-lactide-co-glycolide) (PLGA), which can be easily separated from... [Pg.276]

Karikari A, Mather BD, Long TE. Association of star-shaped poly(D,L-lactide)s containing nucleobase multiple hydrogen bonding. Biomacromolecules 2007 8 302-308. [Pg.97]

Preparation of poly(A-vinyl-2-pyrrolidone)-b-poly(D,L-lactide)... [Pg.486]

TABLE 2. Physical Properties of Selected Poly(7V-vinyl-2-pyrrolidone)-A-poly-(D,L-lactide) Copolymers Prepared According to the Current Invention... [Pg.487]

Amphiphilic poly[()V-vinyl-2-pyrrolidone)-h-poly(D,L-lactide)] was previously prepared by the authors (1) and used in drug device applications. [Pg.487]

Capan, Y., Woo, B.H., Gebrekidan, S., Ahmed, S., and Deluca, P.P. (1999). Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L- lysine) complexed plasmid DNA. J. Control. Release, 60, 279-286. [Pg.303]

Shameem, M., Lee, H., Burton, K., Thanoo, B.C., and Deluca, P.P. (1999). Effect of gamma-irradiation on peptide-containing hydrophilic poly (d,l-lactide-co-glycolide) microspheres. PDA J. Pharmaceut. Sci. Tech., 53, 309-313. [Pg.306]

Yamamoto, Y, Y. Nagasaki, Y. Kato, Y. Sugiyama, and K. Kataoka (2001). Long-circulating polyethylene glycol)-poly(D-L-lactide) block copolymer micelles with modulated surface chacfcjdSontrolled Release, 77 27-38. [Pg.132]

Li Z, Huang L (2004) Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-l-proline). J Control Release 98 437 146... [Pg.246]

Ammoury, N., Fessi, H., et al. In vitro release kinetic pattern of indomethacin from poly(D,L-lactide) nanocapsules. J. Pharm. Sci. 79(9) 763-767, 1990. [Pg.300]

Ravivarapu, H. B., Lee, H., and DeLuca, P. P. Enhancing initial release of peptide from poly(D,L-lactide-co-glycolide) (PLGA) microspheres by addition of a porosigen and increasing drug load. Pharm. Dev. Techrwl. 5(2) 287-296, 2000. [Pg.302]

Hausberger, A. G., Kenley, R. A., and DeLuca, P. P. Gamma irradiation effects on molecular weight and in vitro degradation of poly(D,L-lactide-CO-glycolide) microparticles. Pharm. Res. 12(6) 851—856, 1995. [Pg.302]

See other pages where Poly D,L lactide is mentioned: [Pg.34]    [Pg.38]    [Pg.40]    [Pg.578]    [Pg.140]    [Pg.60]    [Pg.56]    [Pg.62]    [Pg.240]    [Pg.312]    [Pg.640]    [Pg.645]    [Pg.161]    [Pg.179]    [Pg.33]    [Pg.70]    [Pg.88]    [Pg.487]    [Pg.287]    [Pg.27]    [Pg.28]    [Pg.300]    [Pg.300]   
See also in sourсe #XX -- [ Pg.84 ]



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D,L-lactide

D-lactide

L-lactide

Lactid

Lactides

Poly lactide

Poly-D-lactide

Poly[l-

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