In vitro degradation

Andry, M. C. Levy, M. C. (1997). In vitro degradation of serum albumin microcapsules Effect of process variables. International Journal of Pharmaceutics, Vol. 152, 2, (Jime 1997), pp. (145-151), ISSN 0378-5173... 

Reed AM and Gilding DK. Biodegradable polymers for use in surgery-poly(ethylene oxide) poly (ethylene terephthalate) (PEO/PET)copolymers 2. in vitro degradation [J]. Polymer, 1981, 22,499-504. Van Blitterswijk CA, Brink JVD, Eeenders H, et al. The effect of PEG ratio on degradation, calcification and bone bonding of PEO/PBT copolymer (Polyactive). Cell Mater, 1993, 3(1), 23-36. 

Hayen H, Deschamps AA, Grijpma DW, Feijen J, and Karst U. Liquid chromatographic-mass spectro-metric studies on the in vitro degradation of a poly(ether ester) block copolymer. J Chromatogr A, 2004, 1029, 29-36. 

Deschamps AA, van Apeldoom AA, Hayen H, et al. In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly (butylene terephthalate)[J]. Biomaterials, 2004, 25, 247-258. 

Pego AP, Poot AA, Grijpma DW, and Feijen J. In vitro degradation of trimethylene carbonate based (co) polymers. Macromol Biosci, 2002, 2, 411 19. 

Skaija GA and Woodhouse KA. In vitro degradation and erosion of degradable, segmented pol3mreth-anes containing amino acidbased chain extender. J Biomater Sci Polym Ed, 2001, 12, 851-873. Fromstein JD and Woodhouse KA. Elastomeric biodegradable polyurethane blends for soft hssue application. J Biomater Sci Polym Ed, 2002, 13, 391 06. 

Poly(CTTH) (Figs. 6 and 7) was also used as a model compound for the preliminary evaluation of the in vitro degradability of tyro-sine-derived poly(iminocarbonates) Solvent cast films of poly(CTTH)... 

Stehmeier LG, TR Jack, G Voordouw (1996) In vitro degradation of dicyclopentadiene by microbial consortia isolated from hydrocarbon-contaminated soil. Can J Microbiol 42 1051-1060. 

The in vitro degradation profiles of several TDI poly(phosphoester-ure thanes) are shown in Figure 2. It is not possible from this study to correlate the decomposition kinetics with the chemical structure, except for the fact that biodegradability is demonstrated. The in vitro release of 5-FU from PPU-7 is shown in Figure 3. After an initial burst, a reasonably steady and sustained release followed. The UV spectrum of the released 5-FU was identical to that of pure 5-FU, suggesting the chemical integrity of the drug. 

The CAT model considers passive absorption, saturable absorption, degradation, and transit in the human small intestine. However, the absorption and degradation kinetics are the only model parameters that need to be determined to estimate the fraction of dose absorbed and to simulate intestinal absorption kinetics. Degradation kinetics may be determined in vitro and absorption parameters can also be determined using human intestinal perfusion techniques [85] therefore, it may be feasible to predict intestinal absorption kinetics based on in vitro degradation and in vivo perfusion data. Nevertheless, considering the complexity of oral drug absorption, such a prediction is only an approximation. 

Li X, Deng X, Yuan M et al (2000) In vitro degradation and release profiles of poly-DL-lactide-poly(ethylene glycol) microspheres with entrapped proteins. J Appl Polym Sci 78 140-148... 

In vitro Degradation, Erosion, and Drug Release Kinetics... 

The in vitro degradation and drug release of polyanhydride formulations is not necessarily equivalent to the in vivo kinetics. For information on the in vivo kinetics, the interested reader is referred to the recent review by Katti et al. (2002) and the review by Domb et al. (1997). 

Yu G, Wen X, Li R, Qian Y (2006) In vitro degradation of a reactive azo dye by crude ligninolytic enzymes from nonimmersed liquid culture of Phanerochaete chrysosporium. Process Biochem 41(9) 1987-1993... 

Bl 1. Briozzo, P., Morisset, M., Capony, F., Rougeot, C., and Rochefort, H., In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res. 48, 3688-3692 (1988). 

I. Armentano, M. Dottori, D. Puglia, ).M. Kenny, Effects of carbon nanotubes (CNTs) on the processing and in-vitro degradation of poly(DL-lactide-co-glycolide)/CNT films, Journal of Materials Science-Materials in Medicine, vol. 19, pp. 2377-2387, 2008. 

G. K. E. Scriba, Synthesis and in vitro Degradation of Testosterone-Lipid Conjugates , Arch. Pharm. 1995, 328, 271 -276. 

Nepovim, A., Hubalek, M., Podlipna, R., Zeman, S., and Vanek T., 2004, In vitro degradation of 2,4,6-trinitrotoluene by plant tissue culture of Solanum aviculare and Rheumpalmatum,. Eng. Life Sci. 24 46-49. 

Veervort, L., and Kinget, R., In vitro degradation by colonic bacteria of insulin-HP ineorpo-rated in Eudragit RS films, Int J. Pharm., 129 185-190 (1996). 

Gimenez S, Ponsart S, Coudane J, Vert M (2001) Synthesis, properties and in vitro degradation of carboxyl-bearing PCL. J Bioact Compat Polym 16 32 6... 

Theiler S, Teske M, Keul H, Sternberg K, Moller M (2010) Synthesis, characterization and in vitro degradation of 3D-microstmctured poly(E-caprolactone) resins. Polym Chem 1 1215-1225... 

BL Worobey, GRB Webster. In vitro degradation of difluorobenzuron (dimilin) during derivatization with perfluoroanhydrides. J Chromatogr 153 423-431, 1978. 

To improve the absorption of peptides and proteins, the employment of different enzymatic inhibitors has been suggested. For example, some authors have demonstrated the usefulness of inhibitors of both exo- and endopeptidases to promote calcitonin absorption across rat vaginal mucosa [93]. A direct relationship was found between the effect of peptidase inhibitors of in vitro degradation constant of calcitonin in vaginal mucosa homogenates and in vivo promotion of drug absorption, indicated by the decrease in plasma calcium levels after calcitonin administration in rats. The peptidase inhibitors tested were pepstatin, bestatin, and leupeptin. 

Helder, J., Dijkstra, P., and Feijen, F. J. In vitro degradation of glycine/DL-lactic acid copolymers. J. Biomed. Mater. Res. 24 1005-1020, 1990. 

Hausberger, A. G., Kenley, R. A., and DeLuca, P. P. Gamma irradiation effects on molecular weight and in vitro degradation of poly(D,L-lactide-CO-glycolide) microparticles. Pharm. Res. 12(6) 851—856, 1995. 

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