Poly cyanoacrylate nanoparticles

Couvreur, P. Kante, B. Roland, M. Guiot, P. Baudhuin, P. Speiser, P. Poly(cyanoacrylate) nanoparticles as potential lysosomotropic carriers preparation, morphological and sorptive properties. J. Pharm. Pharmacol. 1979, 31, 331-332. 

Calvo P et al (2001) PEGylated poly cyanoacrylate nanoparticles as vector for drug delivery in prion diseases. J Neurosci Methods 111(2) 151-155... 

Arias, J.L., Gallardo, V., Gomez-Lopera, S.A., Plaza, R.C. and Delgado, A.V. (2001) Synthesis and characterization of poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core. Journal of Controlled Release, 77, 309-321. 

Figure 4. Preparation conditions used in the preparation of poly(alkyl-cyanoacrylate) nanoparticles.

Alyautdin R, Gothier D, Petrov V, Kharkevich D, Kreuter J (1995) Analgesic activity of the hexa-peptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles. Eur J. Pharm Biopharm 41 44 48. 

Peracchia MT, Vauthier C, Puisieux F, Couvreur P (1997) Development of sterically stabilized poly(isobutyl 2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol). J Biomed Mater Res 34 317-326. 

Qaddoumi et al. [65] studied the uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell culture. The highest uptake by cultured conjunctival cells was achieved for the smallest particles (100 nm), compared to larger 800 nm and 10 pm particles. A study of the fate of the tiny 100-nm particles following 2 h of cultured cells exposure to a 0.5 mg/mL dose showed that 6% was internalized by conjunctival epithelial cells, 1.5% was surface-bound, whereas the remainder of the dose was found in the donor medium. In an in vivo rabbit eye study [66] on the uptake of poly(hexyl cyanoacrylate) nanoparticles, 6 h postinstillation into the conjunctival sac, it was found that the fraction that was internalized by conjunctival epithelial cells was only 1% of the dose reflecting in vivo precorneal elimination... 

Chauvierre, C., D. Labarre, et al. (2003). Novel polysaccharide-decorated poly(isobutyl cyanoacrylate) nanoparticles. Pharm Res 20(11) 1786-93. 

Yang, S. C., H. X. Ge, et al. (2000). Formation of positively charged poly(butyl cyanoacrylate) nanoparticles stabilized with chitosan. Colloid Polym. Sci. 278 285-292. 

Poly(alkyl cyanoacrylate) nanoparticles accumulate in the liver (60-90% of the injected dose) and the spleen upon iv injection, with the macrophages in the liver being their major target. Nanoparticles loaded with doxorubicin have shown a markedly enhanced therapeutic index in a number of animal tumor models. 

Lambert et al. [48] used poly(isobutyl cyanoacrylate) nanoparticles for the delivery of oligonucleotides. Nanoparticles of size ranging from 20-400 nm were prepared. The authors claimed that this technology might offer interesting perspectives for DNA and peptide transport and delivery. 

Poly(alkyl-cyanoacrylates) As poly(alkyl-cyanoacrylates) form strong bonds with polar substrates including the skin and living tissues, they exhibit bioadhesive properties. These polymers are synthesized by free-radical, anionic, or zwitterionic polymerization. As detailed in a recent review, poly(alkyl-cyanoacrylate) nanoparticles are prepared by emulsion polymerization, interfacial polymerization, nanoprecipitation, and emulsion-solvent evaporation methods [102],... 

Poly(alkyl-cyanoacrylate) Nanoparticles The applications of poly(alkyl-cyanoacrylate) nanoparticles have been reviewed elsewhere and therefore only representative examples are described [102], Because of their adhesive properties, nanoparticles have the potential to prophylactically treat candidiasis of the oral cavity [121], Not surprisingly, poly(alkyl-cyanoacrylate) nanoparticles have been used to deliver drugs to tumors [122], Enhanced absorption and prolonged hypoglycemic effect were observed when insulin was delivered in poly(alkyl-cyanoacrylate) nanoparticles [121], Nuclear accumulation of antisense oligonucleotides into vascular smooth muscle cells was increased when delivered using poly(alkyl-cyanoacrylate) nanoparticles [123]. Dextran-coated poly(alkyl-... 

Vauthier, C., Dubernet, C., Chauvierre, C., Brigger, I., and Couvreur, P. (2003), Drug delivery to resistant tumors The potential of poly(alkyl cyanoacrylate) nanoparticles, /. Controlled Release, 93(2), 151-160. 

Bootz, A., et al. (2004), Comparison of scanning electron microscopy, dynamic light scattering and analytical ultracentrifugation for the sizing of poly(butyl cyanoacrylate) nanoparticles, Eur. J. Pharm. Biopharm., 57(2), 369-375. 

Ilium, L. Jones, P.D. Baldwin, R.W. Davis, S.S. Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mic bearing human... 

Lenaerts, V. Couvreur, P. Christiaens-Leyh, D. Joiris, E. Roland, M. Rollman, B. Speiser, P. Degradation of poly(isobutyl cyanoacrylate) nanoparticles. Biomaterials 1984, 5, 65-68. 

Peracchia, M.T. Vauthier, C. Passirani, C. Couvreur, P. Labarre, D. Complement consumption by poly(ethylene glycol) in different conformations chemically coupled to poly(isobutyl 2-cyanoacrylate) nanoparticles. Life Sci. 1997,... 

Krauel, K., Graf, A., Hook, S., Davies, N.M. and Rades, T. (2006) Preparation of poly (Alkyl-cyanoacrylate) nanoparticles by polymerization of water-free microemulsions. /. Microencap-sul, 23, 499-512. 

Bertholon I, Ponchel G, Labarre D (2006). Bioadhesive properties of poly(alkyl-cyanoacrylate) nanoparticles coated with polysaccharide. J. Nanosci. Nanotechnol. 6 3102-3109. 

Ambruosi A, Khalansky AS, Yamamoto H et al (2(X)6) Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to gUoblastoma-bearing rats. J Drug Target 14 97-105... 

Polysorbate 80 (PS80)-coated poly(n-butyl cyanoacrylate) nanoparticles (PBCA-NP) Transient disruption of the BBB 1821... 

Cationic lipids and cationic polymers are designed as gene delivery systems on the nanoscale. Especially chitosan is under focus as a biodegradable, natural biopolymer, used both as the polyplex and also as a coating material for other polyplexes. Chitosan-coated poly(isohexyl cyanoacrylate) nanoparticles have also been developed for intravenous delivery of siRNA and no evidence of toxicity was observed after intravenous administration for 30... 

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