Poly aminoethyl methacrylate

A further step towards efficient biomedical application of PU/PUR nanocapsules was shown by the work of Paiphansiri et al. [190]. Carboxy- and amino-functionalization of the nanocapsules surface can be introduced and tailored by an in situ carboxymethylation reaction or by physical adsorption of a cationic polyelectrolyte, i.e., poly(aminoethyl methacrylate hydrochloride) or poly(ethylene imine) (see Fig. 21). Encapsulation of an aqueous solution of suforhodamine adds a fluorescent label for fluorescence microscopic detection (see Fig. 21). Whereas the carboxy-functionalized nanocapsules do not lead to a good uptake into cells, the increased uptake of amino-functionalized fluorescent nanocapsules by HeLa cells clearly demonstrates the potential of the functionalized nanocapsules to be successfully exploited as biocarriers. These results are in good agreement with the data obtained from experiments with PS particles [192]. 

Fig. 21 Functionalization of nanocapsules by (a) carboxymethylation reaction or (b) adsorption of poly(aminoethyl methacrylate) (PAEMA) or poly(ethylene imine) (PEI) onto PU nanocapsules (c) and uptake of amino-functionalized (PEI) nanocapsules in cells [190]...

The target was immobilized on monodisperse macroporous poly ((A-methyl)aminoethyl methacrylate-co-methyl methacrylate-co-ethylene di-... 

Fig. 11 Chemical formulas of poly(acryl amide) (PAAm), poly(methyl methacrylate) (PMMA), poly(2-hydroxyethyl methacrylate) (PHEMA), poly(t-butyl acrylate) (PtBA), and poly(acrylic acid) (PAA), and poly(dimethyl aminoethyl methacrylate) (PDMAEMA)...

While the bulk behavior of polyampholytes has been investigated for some time now, studies of interfacial performance of polyampholytes are still in their infancy. There are several reasons for the limited amount of experimental work the major one being the rather complex behavior of polyampholytes at interfaces. This complexity stems from a large array of system parameters governing the interaction between the polymer and the substrate. Nearly all interfacial studies on polyampholytes reported to-date involved their adsorption on solid interfaces. For example, Jerome and Stamm and coworkers studied the adsorption of poly(methacryhc acid)-block-poly(dimethyl aminoethyl methacrylate) (PMAA-fc-PDMAEMA) from aqueous solution on sihcon substrates [102,103]. The researchers found that the amount of PMAA-fo-PDMAEMA adsorbed at the solution/substrate interface depended on the solution pH. Specifically, the adsorption increased... 

The temperature optimization for the RAFT polymerization of EAA revealed an optimum reaction temperature of 70 °C. Block copolymers with a poly(methyl acrylate) (PMA), a poly(n-butyl acrylate) (PnBA), a PMMA, or a poly(A,A-dimethyl aminoethyl methacrylate) (PDMAEMA) first block and a poly(l-ethoxyethyl acrylate) (PEEA) second block were successfully synthesized in an automated synthesizer. The synthesis robot was employed for the preparation of 16 block copolymers consisting of 25 units of the first block composed of PMA (exp. 1 ), PnBA (exp. 5-8), PMMA (exp. 9-13), and PDMAEMA (exp. 13-16) and a second block of PEEA consisting of 25, 50, 75, or 100 units, respectively. The first blocks were polymerized for 3 h and a sample from each reaction was withdrawn for SEC analysis. Subsequently, EAA was added and the reactions were continued for 12 h. The molar masses and PDI values of the obtained block copolymers are shown in Fig. 15. 

Figure 11.5. Changes in molecular weight of the template during copolymerization of methyl methacrylate with methacrylic acid. Template poly(dimethyl aminoethyl methacrylate) PDAMA.

Another complex obtained by template polymerization of dimethylaminoethyl methacrylate in the presence of polyCacrylic acid) was synthesized and analyzed by Abd-Ellatif. The procedure of separation was as follows to the complex dissolved in 10% NaCl solution, 10% NaOH solution was added dropwise and white gel was precipitated. Addition of sodium hydroxide was continued until no more precipitate was separated. The soluble polymer after dialysis was dried and identified as poly(acrylic acid). The insoluble polymer fraction was found to be insoluble in toluene, benzene, tetrahydrofurane, but soluble in acetone/water (2 1 v/v). Elemental analysis and IR spectra lead to the conclusion that this fraction consists of pure poly(dimethyl aminoethyl methacrylate) which was expected as a daughter polymer. 

Polyfructan (inulin) of MW 30-50 million was synthesized from sucrose with fructosyltransferase (FTF, inulin sucrase from Streptococcus mutans) immobilized by photoinitiated graft copolymerization with poly(2-aminoethyl methacrylate) in the pores of a 3.0 pm microfiltration membrane (Hicke, 1999). 

Inactive polypropylene powder, when treated with N,N-dimethyl-aminoethyl methacrylate and benzoyl peroxide in hexane at 30°C. did not possess detectable amounts of —COOR absorbance. The absence of —COOR absorbance in the resultant polymer gives further evidence that N,N-dimethylaminoethyl methacrylate either did not polymerize under the conditions used or formed only a very low molecular weight polymer which was washed out by the finishing procedure used. It also established that an active polymer chain is necessary and that poly (N,N-di-methylaminoethyl methacrylate) does not exist as a mixture with polypropylene but is tied into the polypropylene chain. 

Poly(dimethyl-aminoethyl) methacrylate Polymer for surface passivation of semiconductor nanocrystals... 

Poly(2-hydroxyisopropylactylate-co-aminoethyl methacrylate) water 2009DEN... 

Poly(2-hydroxyethyl acrylate-co-2-hydroxyethyl methacrylate) Poly(2-hydroxyethyl acrylate-co-hydroxypropyl acrylate) Poly(2-hydroxyethyl acrylate-co-vinyl butyl ether) Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Poly(2-hydroxyethylmethacrylate-6-A -isopropylacrylamide) Poly(2-hydroxyisopropyl acrylate-co-aminoethyl methacrylate) Poly(2-hydroxypropyl acrylate-co-A -acryloylmorpholine) Poly(2-hydroxypropyl acrylate-co-aminoethyl methacrylate) Poly(2-hydroxypropyl acrylate-co-A. A -dimethylaciylamide) Poly[A -(2-hydroxypropyl)methacrylamide-Zr-A -isopropylacrylamide] Poly [A -(2-hydroxypropyl)methacrylamide monolactate-co-A -(2-hydroxypropyl) methacrylamide dilactate]... 

By using reaction between amines and carboxylic acid, Zhang and coworkers reported the preparation of ferrocene-based shell cross-linked (SCL) thermoresponsive hybrid micelles with antitumor efficacy. The SCL micelle consisting of a cross-linked thermoresponsive hybrid shell and a hydrophobic core domain was fabricated via a two-step process micellization of poly(Af-isopropylacrylamide-co-aminoethyl methacrylate)- -polymethyl methacrylate P(NIPAAm-co-AMA)- -PMMA in aqueous solution followed by cross-linking of the hydrophilic shell layer via the amidation reaction between the amine groups of AMA units and the carboxylic acid functions of l,r-ferrocenedicarboxylic acid. ... 

P(DMAEMA-EGMA) Poly(2-dimethyl aminoethyl methacrylate-ethylene glycol dimethacrylate)... 

In the case of weakly ionizable PEs, the fraction of charged monomer units, a, is controlled by an ionization equilibrium and is affected by the local proton concentration and ionic strength. Weak polyacids such as poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA), or polybases such as PVP and poly(dimethyl-aminoethyl methacrylate)(PDMAEMA) are typical examples of these pH-sensitive or annealing PEs. 

Ma L, Liu RG, Tan JJ, Wang DQ, Jin X, Kang HL, Wu M, Huang Y (2010) Self-assembly and dual-stimuli sensitivities of hydroxypropylcellulose-graft-poly(N, N-dimethyl aminoethyl methacrylate) eopolymers in aqueous solution. Langmuir 26 8697-8703... 

Scheme 1.4 Introduction of ester bonds into the backbone of poly[2-(Ar -dimethyI-aminoethyl) methacrylate].

Plasma grafting of poly 2-(A,A-dimethyl) aminoethyl methacrylate on a micro-porous PE substrate resulted in the membrane having amine moieties (Matsuyama et al. 1996). This membrane showed high permselectivity for CO2 over Nj (130 for swollen membrane). 

Matsuyama, H., Teramoto, M. and Sakakura, H. 1996. Selective permeation of COj through poly 2-(N,N-dimethyl) aminoethyl methacrylate membrane prepared by plasma-graft polymerization technique. 

---