Thrombocytopenia, drug-induced

Wazny LD, Ariano RE. Evaluation and management of drug-induced thrombocytopenia in the acutely ill patient. Pharmacotherapy 2000 20(3) 292-307. 

Kroll H, Sun QH, Santoso S. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia. Blood 2000 96(4) 1409-14. 

Bottiger L, Westerholm B. Thrombocytopenia. II. Drug-induced thrombocytopenia. Acta Med Scand 1973 191 541-548. 

George JN, Raskob GE, Haha SR, et al. Drug-induced thrombocytopenia a systematic review of published cases. Ann Intern Med 1998 129 886-890. 

Patnode NM, Gandhi PJ. Drug-induced thrombocytopenia in the coronary care unit. J Thromb Thrombolysis 2000 10(2) 155-67. 

Acute thrombocytopenic purpura has been reported in three patients given contrast agents (SEDA-11, 413). Severe thrombocytopenia has rarely been reported after iopanoic acid (128), iocetamic acid (129), and sodium iopo-date in the last case there was evidence that the patient had developed platelet antibodies of the type associated with other drug-induced thrombocytopenias (130). 

Kimura S, Shorota N. [A case report of massive bleeding from conjunctiva due to drug-induced thrombocytopenia.] Nippon Ganka Kiyo 1971 22(ll) 954-8. 

Reports of drug-induced thrombocytopenia have been systematically reviewed (1). Among the 98 different drugs described in 561 articles the following antibiotics were found with level I (definite) evidence co-trimoxa-zole, rifampicin, vancomycin, sulfisoxazole, cefalothin, piperacillin, methicillin, novobiocin. Drugs with level II (probable) evidence were oxytetracycline and ampicillin. 

Kelton JG, Meltzer D, Moore J, Giles AR, Wilson WE, Barr R, Hirsh J, Neame PB, Powers PJ, Walker I, Bianchi F, Carter CJ. Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro. Blood 1981 58(3) 524-9. 

Willert C, Englisch S, Schlesinger S, Runge U. Possible drug-induced thrombocytopenia secondary to tiagabine. Neurology 1999 52(4) 888. 

The third mechanism described for drug-induced thrombocytopenia is the innocent bystander-type immune response. The most commonly implicated drug is quinidine, and the drug-induced thrombocytopenia is frequently related to higher doses of the drug. Quinidine may also form a hapten with the platelet membrane to produce thrombocytopenia. ... 

Miescher PA, Graf J. Drug-induced thrombocytopenia. CUn Haematol 1980 9 505-519. 

Pedersen-Bjergaard U, Andersen M, Hansen PB. Drug-induced thrombocytopenia CUnical data on 309 cases and the effect of corticosteroid therapy. Eur J CUn Pharmacol 1997 52 183-189. 

Heparin-induced thrombocytopenia (HIT). Most frequent antibody-mediated drug-induced thrombocytopenia. Occurs in 1-2% of patients treated with heparin intravenously for longer than four days. Mediated by antibodies to complexes formed between heparin and the endogenous platelet factor 4 (PF4). 

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