Plasma primary

Plasma Measure plasma Primary adrenal insufficiency low plasma aldosterone level. ... 

Primary blood components iaclude plasma, red blood cells (erythrocytes), white blood cells (leukocytes), platelets (thrombocytes), and stem cells. Plasma consists of water dissolved proteias, ie, fibrinogen, albumins, and globulins coagulation factors and nutrients. The principal plasma-derived blood products are siagle-donor plasma (SDP), produced by sedimentation from whole blood donations fresh frozen plasma (FFP), collected both by apheresis and from whole blood collections cryoprecipitate, produced by cryoprecipitation of FFP albumin, collected through apheresis and coagulation factors, produced by fractionation from FFP and by apheresis (see Fractionation, blood-plasma fractionation). 

Once a fusion reaction has begun in a confined plasma, it is planned to sustain it by using the hot, charged-particle reaction products, eg, alpha particles in the case of D—T fusion, to heat other, colder fuel particles to the reaction temperature. If no additional external heat input is required to sustain the reaction, the plasma is said to have reached the ignition condition. Achieving ignition is another primary goal of fusion research. 

Fusion energy research is also the primary avenue for the development of plasma physics as a scientific discipline. The technologies and the science of plasmas developed en route to fusion power are already important in other appHcations and fields of science (see Plasma technology). 

Fig. 21. Schematic illustration of the four primary vapor-phase deposition processes used in optical-fiber fabrication outside vapor deposition (OVD), modified chemical vapor deposition (MCVD), plasma vapor deposition (PVD), and vapor axial deposition (VAD) (115).

The primary characteristic frequency of an ordinary gas is the rate of coUision f = V/X = ttVnD, where V is the mean particle velocity, and V = [SkT for particles of mass m. Among the special frequencies associated with plasmas, the most notable is the plasma frequency ... 

Impacts and Explosives. The coUision of high velocity bullets or other projectiles with soHds causes rapid conversion of kinetic to thermal energy. Plasmas result iacidentaHy, whereas the primary effects of impact are shock and mechanical effects in the target. Impact-produced plasmas are hot enough to cause thermonuclear bum (180). 

Transport. Transcobalamin II dehvers the absorbed vitamin 3 2 to cells and is the primary plasma vitamin B22-binding transport protein. It is found in plasma, spinal fluid, semen, and extracellular fluid. Many cells, including the bone marrow, reticulocytes, and the placenta, contain surface receptor sites for the transcobalamin II—cobalamin complex. 

Procainamide may be adininistered by iv, intramuscular (im), or po routes. After po dosing, 75—90% of the dmg is absorbed from the GI tract. About 25% of the amount absorbed undergoes first-pass metaboHsm in the fiver. The primary metabolite is A/-acetylprocainamide (NAPA) which has almost the same antiarrhythmic activity as procainamide. This is significant because the plasma concentration of NAPA relative to that of procainamide is 0.5—2.5. In terms of dmg metabolism there are two groups of patients those that rapidly acetylate and those that slowly acetylate procainamide. About 15—20% of the dmg is bound to plasma proteins. Peak plasma concentrations are achieved in 60—90 min. Therapeutic plasma concentrations are 4—10 lg/mL. Plasma half-lives of procainamide and NAPA, which are excreted mainly by the kidneys, are 2.5—4.5 and 6 h, respectively. About 50—60% is excreted as unchanged procainamide (1,2). 

Esmolol is iv adrninistered. Maximal P-adrenoceptor blockade occurs in 1 min. Its elimination half-life is about 9 min. EuU recovery from P-adrenoceptor blockade is within 30 min after stopping the infusion. The therapeutic plasma concentrations are 0.4—1.2 lg/mL. It is metabolized by hydrolysis in whole blood by red blood cell esterases resulting in the formation of a primary acid metabohte and free methanol. The metabohte is pharmacologically inactive. The resulting methanol levels are not toxic. Esmolol is 55% bound to plasma protein, the acid metabohte only 10%. Less than 2% of parent dmg and the acid metabohte are excreted by the kidneys. Plasma levels may be elevated and elimination half-hves prolonged in patients with renal disease (41). 

The GI absorption of the dmg after po adrninistration is slow and variable with estimates ranging from 20—55%. Once absorbed, 96% of the dmg is bound to plasma proteins and other tissues on the body. Whereas peak plasma concentrations may be achieved in 3—7 h, the onset of antiarrhythmic action may occur in 2—3 days or more. This may result, in part, from distribution to and concentration of the dmg in adipose tissue, Hver, spleen, and lungs. Therapeutic plasma concentrations are 1—2 p.g/mL, although there appears to be no correlation between plasma concentration and antiarrhythmic activity. The plasma half-life after discontinuation of the dmg varies from 13—103 days. The dmg is metabolized in the Hver and the principal metaboHte is desethylamiodarone. The primary route of elimination is through the bile. Less than 1% of the unchanged dmg is excreted in the urine. The dmg can also be eliminated in breast milk and through the skin (1,2). 

A few mm in direct plasma sputtering 0.1—10 pm using separate, focused primary ion-beam sputtering... 

Figure 2 Relationship of SIMS, separate bombardment SNMSs and direct bombardment SNMSd. (a) Materials for SIMS analysis are those ions formed In the sputtering with a focused primary ion beam. The largest fraction of the particles sputtered from the surface are neutral atoms, (b) Ions for SNMS analysis are formed by ionization of the sputtered neutrals, (c) When the plasma is used as an ionizer, plasma ions can also be used to sputter the sample surface at low energies.

Several ion sources are particularly suited for SSIMS. The first produces positive noble gas ions (usually argon) either by electron impact (El) or in a plasma created by a discharge (see Fig. 3.18 in Sect. 3.2.2.). The ions are then extracted from the source region, accelerated to the chosen energy, and focused in an electrostatic ion-optical column. More recently it has been shown that the use of primary polyatomic ions, e. g. SF5, created in FI sources, can enhance the molecular secondary ion yield by several magnitudes [3.4, 3.5]. 

In this chapter, we have examined coupled transport systems that rely on ATP hydrolysis, on primary gradients of Na or Ff, and on phosphotransferase systems. Suppose you have just discovered an unusual strain of bacteria that transports rhamnose across its plasma membrane. Suggest experiments that would test whether it was linked to any of these other transport systems. 

The pharmacokinetics of azacitidine shows that it is rapidly absorbed after s.c. administration with the peak plasma concentration occurring after 0.5 h. The bioavailability of s.c. azacitidine relative to i.v. azacitidine is approximately 89%. Urinary excretion is the primary route of elimination of azacitidine and its metabolites. The mean elimination half-lives are about 4 h, regardless of i.v. or s.c. administration. 

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