Phototoxic

Thus, multiphoton excitation eliminates unwanted out-of-focus excitation, lumecessary phototoxity and bleaching. However, efficient power sources are required and, since the efficiency of multiphoton excitation is usually low, the times needed to generate unages are mcreased. 

Phototoxicity is negative for all oils except bergamot, expressed, for which it is severe. 

Irradiation of lomefloxacin 271 in dilute neutral aqueous solution (in which it exists as a zwitter ion) in Pyrex-filtered 500 W medium pressure mercury (Helios Italquartz) at 17°C gave pyrrolo[3,2,l-(/ ]quinoline 272 (99JOC5388). Under this condition, reductive defluorination via a radical anion took place. This study is important because of the phototoxicity of the fluorinated compounds which could be used as antibacterials (Scheme 49). 

A number of quinolones had to be taken off the market due to toxic effects on the liver, heart, or other organs, that became recognized only after marketing (e.g. temafloxacin, trovafloxacin, grepafloxacin). A risk for severe cardiotoxicity, hepatotoxicity, or phototoxicity is... 

The combination of methotrexate and UVB seems to be synergistic responses may occur with lower cumulative doses of both methotrexate and UVB. However, stopping methotrexate may cause rebound21,33 and there is some concern about photosensitivity.21 Methotrexate and PUVA have been used together in patients refractory to other treatments however, there is additive carcinogenesis (especially increasing the risk of squamous cell cancer) and subacute phototoxicity.21... 

Adverse effects with the tetracyclines include gastrointestinal upset drug interactions with dairy products, antacids, and iron and phototoxicity. Minocycline can also cause vestibular complications (headache and dizziness) and skin discoloration that is not typical with tetracycline and doxycycline.16... 

Tetracycline Tablets, capsules 250, 500 mg 500 mg twice daily before meals Maintenance dose 500 mg daily Gl upset, phototoxicity, tooth discoloration, drug and food interactions... 

Phototoxicity caused by drugs is a problem that is being observed with greater frequency. The primary... 

Bohm, F, Edge, R, Foley, S, Lange, L, and Truscott, TG, 2001. Antioxidant inhibition of porphyrin-induced cellular phototoxicity. J Photochem Photobiol B 65, 177-183. 

Rozanowski, B, Cuenco, J, Davies, S, Shamsi, FA, Zadlo, A, Dayhaw-Barker, P, Rozanowska, M, Sarna, T, and Boulton, ME, 2008c. The phototoxicity of aged human retinal melanosomes. Photochem Photobiol 84, 650-657. 

Keywords Dual-wavelength ratiometry Electrochromism Ion-transporting membrane proteins Membrane dipole potential Phototoxicity... 

Bioassays of a considerable number of drugs embodying a combination of porphyrin and cis-platin moieties in the same molecule have led to compound (43) in vitro and in vivo studies on this compound showed a phototoxicity which was additive to the cytotoxic effect of the platinum moiety.190-193... 

The answer is c. (Hardman, pp 1134-1135.) Hematologic toxicity is by far the most important adverse effect of chloramphenicol The toxicity consists of two types (1) bone marrow depression (common) and (2) aplastic anemia (rare) Chloramphenicol can produce a potentially fatal toxic reaction, the gray baby syndrome, caused by diminished ability of neonates to conjugate chloramphenicol with resultant high serum concentrations. Tetracyclines produce staining of the teeth and phototoxicity... 

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