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Phototoxicity, diuretic drugs

The phototoxic diuretic drug furosemide 6, a 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)-amino] benzoic acid, is photolabile under aerobic and anaerobic conditions. Previous studies have established that furosemide causes adverse photosensitizing effects in vivo and has a high in vitro photosensitizing capability. In this context, it is capable of initiating both energy transfer and free radical reactions. Irradiation of a methanol solution of 6 produces under an oxygen atmosphere photoproducts... [Pg.1284]

The phototoxic diuretic drug acetazolamide 7 is photolabile under aerobic and anaerobic conditions in methanoUc solution as well as in buffered aqueous medium (pH = 7.2). The quantum yield under aerobic conditions was 0 = 0.24, and the reaction led to the formation of photoproducts 7a (yield 75%) and 7b (yield 25%) (Figure 63.4). The results indicate that Oj is directly involved in the photol) is of acetazolamide. The study of the influence of oxygen radicals on the decomposition of acetazolamide (irradiations in the presence of singlet oxygen quenchers) indicate that Oj may lead to degradation of 7 by oxygenation. [Pg.1284]

Mechanistic Studies on the Photochemistry and Phototoxicity of Diuretic Drugs... [Pg.1282]

Amiloride 12, another potent diuretic drug, shows a similar behavior under irradiation in the UV-A-Vis region, producing dechlorination products, and the photoreaction is pH dependent.Presumably, the strong absorption at 360 nm in the UV-A is responsible for its phototoxic properties (Figure 63.7). ... [Pg.1286]

Vargas, E, Fuentes, A., Sequera, J., Mendez, H., Fraile, G., Veldsquez, M., and Medina, R., In vitro approach to investigate the phototoxicity of the diuretic drug triamterene., Toxicol In Vitro, 12, 661, 1998. [Pg.1291]

Drug-induced photosensitivity reactions are divided into phototoxicity (a nonimmunologic reaction) and photoallergic reactions (an immunologic reaction). The latter form is far less common. Medications associated with photosensitivity reactions include fluoroquinolones, nonsteroidal antiinflammatory drugs, phenothiazines, antihistamines, estrogens, progestins, sulfonamides, sulfonylureas, thiazide diuretics, and tricyclic antidepressants. [Pg.196]

Selvaag, E., Anholt, H., Moan, J., and Thune, R, Inhibiting effects of antioxidants on drug-induced phototoxicity in ceU cultures. Investigation with sulphonamide-derived oral antidiabetics and diuretics,/. Photochem. Photobiol B Biol, 38, 88,1997. [Pg.1290]


See other pages where Phototoxicity, diuretic drugs is mentioned: [Pg.1285]    [Pg.1285]    [Pg.20]    [Pg.1282]    [Pg.1287]    [Pg.209]    [Pg.584]    [Pg.1747]    [Pg.409]    [Pg.1284]    [Pg.1286]   
See also in sourсe #XX -- [ Pg.9 ]




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