Phototoxicity voriconazole

The exact mechanisms of voriconazole-associated photosensitivity are unknown, but inhibition of retinoid metabolism or a direct phototoxic effect of voriconazole or its N-oxide main metabolite, formed by the action of CYP2C19, has been implicated. There was no significant correlation between the incidence of photosensitivity and voriconazole serum concentrations in six children with allergic bronchopulmonary aspergillosis [3T]. In a retrospective study of 24 lung transplant recipients with cystic fibrosis who took voriconazole, heterozygous carriers of the CYP2C19 2 allele required lower maintenance doses than... [Pg.431]

There were similar phototoxic manifestations in two adults who took long-term voriconazole [41 ]. In both patients, voriconazole M os withdrawn and the lesions resolved within 2 weeks. [Pg.432]

Five patients who were initially thought to be having a flare of cutaneous chronic graft-versus-host disease were actually exhibiting phototoxicity due to voriconazole [43 ]. [Pg.433]

Phototoxicity occurred in a 60-year-old man, who took voriconazole for 15 days and developed erythroderma 30 minutes after exposure to intense sunlight, with papulopustular prurigi-nous lesions, vesicles, and bullae [46 ]. [Pg.433]

An 8-year-old boy developed severe phototoxicity after taking voriconazole for treatment and prophylaxis after pulmonary aspergillosis for 1 year he developed blistering eruptions on his face after minimal sunlight exposure [48 ]. [Pg.433]

However, phototoxic reactions due to voriconazole can ako result in true porphyria cutanea tarda, with superficial cheilitis [56 ]. [Pg.433]

A 55-year-old man with pulmonary aspergillosis developed a phototoxic reaction after taking voriconazole for a few months, followed by multiple squamous cell carcinomas on sun-exposed skin areas [65 ]. After voriconazole withdrawal, no new carcinomas were observed. Exploration of gene mutations involved in skin carcinogenesis showed two variants of the MICR gene. [Pg.434]

Epaulard O, Leccia MT, Blanche S, Chosidow O, Mamzer-Bruneel MF, Ravaud P, Thiebaut A, Villier C, Lortholary O. Phototoxicity and photocarcinogenesis associated with voriconazole. Med Mai Infect 2011 41(12) 639 5. [Pg.437]

Vandecasteele SJ, Van Wijngaerden E, Peetermans WE. Two cases of severe phototoxic reactions related to long-term outpatient treatment with voriconazole. Eur J Clin Microbiol Infect Dis 2004 23 656-7. [Pg.437]

Gea-Banacloche J, Mitchell S, Pavletic SZ, Wise B, Cowen EW. Voriconazole-induced phototoxicity masquerading as chronic graft-versus-host disease of the skin in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant 2009 15 370-6. [Pg.437]

Vohringer S, Schrum J, Ott H, Roger PR Severe phototoxicity associated with longterm voriconazole treatment. J Dtsch Dermatol Ges 2011 9(4) 274-6. [Pg.438]

Racette AJ, Roenigk RR Jr, Ransen R, Mendelson D, Park A. Photoaging and phototoxicity from long-term voriconazole treatment in a 15-year-old girl J Am Acad Dermatol 2005 52(5 SuppL 1) S81-5. [Pg.438]

Riahi RR, Cohen PR. Voriconazole-associated phototoxicity. Dermatol Online J 2011 17(2) 15. [Pg.438]

Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP. Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. J Am Acad Dermatol 2010 62(1) 31-7. [Pg.438]

Bernhard S, Kemland Lang K, Ammann RA, Luer S, Leibundgut K, Diepold M, et al. Voriconazole-induced phototoxicity in children. Pediatr... [Pg.390]

Rondeau S, Couderc L, Dominique S, Pramil S, LeguiUon C, MasseBne B, et aL High frequency of voriconazole-related phototoxicity in cystic... [Pg.390]

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