Phototoxicity minocycline

Adverse effects with the tetracyclines include gastrointestinal upset drug interactions with dairy products, antacids, and iron and phototoxicity. Minocycline can also cause vestibular complications (headache and dizziness) and skin discoloration that is not typical with tetracycline and doxycycline.16... 

Minocycline Tablets, capsules 50, 75, 1 00 mg 50 mg twice daily or 100 mg once daily Maintenance dose 50 mg daily Gl upset, phototoxicity, drug and food interactions, vestibular toxicity, skin discoloration... 

Phototoxic reactions are most frequent with demeclocycline, and occur less frequently with the other tetracyclines minocycline is least likely to cause phototoxic reactions. 

Frost P, Weinstein GD, Gomez EC. Phototoxic potential of minocycline and doxycycline. Arch Dermatol 1972 105(5) 681-3. 

Gastrointestinal reactions that may occur during tetracycline administration include nausea, vomiting, diarrhea, epigastric distress, stomatitis, and sore throat. Skin rashes also may be seen. A photosensitivity (phototoxic) reaction may be seen witli tliis group of dni, manifested by an exa rated sunburn reaction when the skin is exposed to sunlight even for brief periods. Demeclocychne seems to cause the most serious photosensitivity reaction, whereas minocycline is least likely to cause this type of reaction. 

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