Phenylmercuric acetate sodium

Oxymetazoline HC1 Naphazoline HC1 Xylometazoline HC1 Tetrahydrozoline HC1 Benzalkonium chloride Phenylmercuric acetate Glycine Sorbitol Sodium chloride Carboxymethylcellulose Microcrystalline cellulose EDTA Chlorhexidine gluconate Eucalyptol Menthol Camphor... 

The reaction of allylic alcohols and aryl halides in the presence of a palladium catalyst has been used in the past to prepare various 0-arylal-dehydes. The procedure described here is essentially that of Heck and Melpolder.3 A similar reaction has been carried out with bromobenzene and 2-methyl-2-propen-l-ol in hexamethylphosphoric triamide (HMPT) as solvent with sodium bicarbonate as base. A variety of other bases have also been used.4 2-Methyl-3-phenylpropanal has been prepared by reacting palladium acetate and phenylmercuric acetate with 2-methyl-2-propen-l-ol.5... 

Some methods of preparing derivatives of the type RHgX haA e already been dealt Avith in describing the reactions of the tyj e R2Hg. In the case of benzene and toluene the mercuration may be carried out directly, using mercuric acetate. If the operation is performed in the presence of alcohol, benzene may be converted to phenylmercuric acetate at 100° C., but the process takes about fifty-five hours to obtain an 80 per cent, yield. When toluene is refluxed Avith mercuric acetate, ortho- and para- ring-substituted compounds are produced. Another method is to treat the aryl sulphinic acids or their sodium salts Avith mercuric chloride, when the folloAving reaction occurs —... 

Fhenylmercuric thiosulphate. — Two molecules of phenylmercuric acetate in ammonium hydroxide—ammonium acetate solution are treated with one molecule of sodium thiosulphate, when a white precipitate is obtained, insoluble in ordinary solvents but dissolving in concentrated hydrochloric acid, with evolution of sulphur dioxide and deposition of sulphur. This thiosulphate readily dissolves in aqueous sodium thiosulphate, the solution giving mercury diphenyl on standing. The compound is not decomposed when heated to 200° C. 

Collins AJ, Lingham P, Burbridge TA, Bain R. Incompatibility of phenylmercuric acetate with sodium metabisulphite in eye drop formulations. ] Pharm Pharmacol 1985 37(SuppL) 123P. 

Sodium alginate is incompatible with acridine derivatives, crystal violet, phenylmercuric acetate and nitrate, calcium salts, heavy metals, and ethanol in concentrations greater than 5%. Low concentrations of electrolytes cause an increase in viscosity but high electrolyte concentrations cause salting-out of sodium alginate salting-out occurs if more than 4% of sodium chloride is present. 

Fig. 17.6 Some organomercurials A, thiomersal (sodium ethylmercurithiosalicylate) B, phenylmercuric acetate.

Derivation Reaction of phenylmercuric acetate and sodium chloride. 

Consumption of animals or poultiy fed fish meal might increase the exposure to MeHg, but data are not available. The use of organic Hg compounds as preservatives in vaccines and medical preparations is also a source of exposure and is of particular importance in young children who might be more sensitive to those mercurials than adults. As many as 219 such products are in use (FDA 1999). Thimerosal (TM) (sodium ethylmercuiithiosalicylate) and phenylmercuric acetate (PMA) are the most frequently used compounds, at concentrations of 0.01% and 0.0002%, respectively. The FDA estimates that 75-80 kg of Hg compounds are used annually by the manufacturers of those vaccines and medical preparations. The risks associated with thimerosal use in vaccines have been discussed in an interim report to clinicians (American Academy of Pediatrics 1999). 

See Mercaptopropyltrimethoxysilane 2-Mercaptopyridine-N-oxide, sodium salt See Sodium pyrithione Mercuric oxide Mercuric oxide, red. See Mercury oxide (ic), red Mercuriphenyl acetate Mercury, (acetato) phenyl-. See Phenylmercuric acetate... 

PMA. See Phosphomolybdic acid Pyromellitic acid Phenylmercuric acetate Propylene glycol methyl ether acetate PMA. See Pyromellitic acid PMAA. See Polymethacryiic acid PMAA, sodium salt. See Sodium poiymethacrylate... 

Dimethylaminopyridine 4,6-Dinitro-o-cresol Diphenylamine Disodium octaborate tetrahydrate Endosulfan Ethiofencarb 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline 2-Ethylhexanal Ethyl hexanediol 2-Ethylhexenal 2-Ethyl-2-hexenal Ethyl-p-nitrobenzoate Etrimfos Fenamiphos Fenpropathrin Fenthion Fluometuron Furfural Glyoxalic, acid Hexachloro-1,3-butadiene Hexachloroethane Hydramethyinon 2-Hydroxy-2-methylpropanenitrile 2-Imidazolidinone lodofenphos Isofenphos Isooctyl thioglycolate Isopropanolamine Kojic acid Laurie acid Lead acetate Lead acetate trihydrate Lead naphthenate 2,6-Lutidine Mecarbam Mercury chloride (ic) Metam-sodium P-Methylnaphthalene Naphthalene Nicotine Oxamyl Parathion-methyl Pentaerythritol Perchloropentacyclodecane Permethrin Phenothiazine Phenylmercuric acetate Phorate Phosalone Phoxim Phthalic anhydride a-Pinene Pine (Pinus palustris) tar oil Piperazine Piperazine dihydrochloride... 

The crj stalline chloride was obtained in 30 per cent, yield by Reitzen-stein and Stamm, the acetate and sodium chloride solution being boiled for thirty minutes. The plates, which were recrystallised from benzene, melted at 240° C. When treated with sodium thiosulphate, p-amino-phenylmercuric thiosulphate is formed, and from the amori hous form Pesci isolated a crystalline product by the action of alcoholic aniline hydrochloride. It crystallised in fine, colourless needles, decomposing above 150° C. 

Schweizer and O Neill, unsuccessful in an attempt to follow the Reutov-Eovtsova procedure using commercial potassium l-butoxide, developed a convenient synthesis of phenyl(trichloromethyl)mercury in which phenylmercuric bromide is treated with trichloroacetate anion generated in large excess from ethyl trichloro-acetate and commercial sodium methoxide. A mixture of 200 ml. of benzene, 0.18 mole of ethyl trichloroacetate, and 0.37 mole of pulverized phenylmercuric bromide is stirred for 1.5 mln< In an ice hath and 0.154 mole of sodium methoxide is added all... 

All the diarylstibinic acids are solids, and their method of preparation has an influence upon their solubility, eg, the hydrolysis of di-phenylstibinic chloride by ammonium hydroxide yields an acid which is insoluble in ammonium hydroxide or sodium carbonate, but dissolves in sodium hydroxide, whilst solution of the chloride in sodium hydroxide gives a stibinic acid on acidification with acetic acid which dissolves in all the foregoing alkalis. The secondary acids also differ from the primary acids in their action towards hydrochloric acid and ammonium chloride diphenylstibmic acid is insoluble in concentrated hydrochloric acid, and m hot dilute hydrochloric acid its solutions do not give a double salt with ammonium chloride, but pyridine hydrochloride precipitates diphenylstibmic chloride as a double salt. Nitration of the secondary stibinic acids yields nitro-acids containing the nitro-group in the meia-position to the antimony. Reduction of the secondary acids yields stibinoxides. Mercuric chloride converts diphenylstibmic acid in methyl alcohol-hydrogen chloride solution into phenylmercuric chloride and antimony trichloride. 

Chloramine-T m-Cresyl acetate D C Red No. 6 D C Red No. 7 Dichlorobenzyl alcohol Hexamidine diisethionate Mercury chloride (ic) Phenethyl alcohol Phenylmercuric borate Resorcinol Zinc carbonate Zinc peroxide antiseptic, topical anti-infectives Cetearyl alcohol Jsopropyl alcohol Sodium iodide... 

Laurylpyridinium bisulfate Methoxyethanol Myristalkonium chloride Nitrosophenylhydroxylamine ammonium salt PCA ethyl cocoyl arginate Phenylmercuric nitrate Phenylmercuric nitrate, basic Phenylmercuric oleate Silver nitrate Sodium arsenate Sodium hypochlorite Sodium lauroamphoacetate Sodium oleoamphopropionate Stearamine 2,2 -Thiobis (4,6-dichlorophenol) 3,5,5-Trimethylhexan-1-ol germicide (duckweed killer), petroleum Stearamine acetate... 

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