2-phenyl-2-propyl chloride

Calculate energies for reaction of 2-methyl-2-propyl chloride (to 2-methyl-2-propyl cation), 2-phenyl-2-propyl chloride (to 2-phenyl-2-propyl cation) mdphenyl chloride (to phenyl cation). (The energy of chloride is given at right.) Assuming that reaction (1) is normal , what is the effect of a benzene ring Does it facilitate or hinder loss of chloride ... 

The recent determination of the calorimetric heats of ionization of representative alkyl chlorides in S02C1F fails to reveal stabilization of this magnitude in the 2-norbornyl system46. For example, the calorimetric heat of ionization of 2-propyl chloride (-15.3 0.9 kcal mol"1) is less than that of tert-butyl chloride (-25.4 0.8) by some 10.1 kcal mol-1. On the other hand, the value for exo-norbornyl chloride (-23.6 0.8) is less than that of 2-methyl-ev -norbomyl chloride (-3.15 1.5) by some 7.4 kcal mol-1. Similarly, the difference between 2-propyl chloride and 2-phenyl-2-propyl chloride (—30.3 0.3) is 15.0 1.2 kcal mol-1, whereas the... 

Phenyl-propyl- -chlorid E2, 248 2-Propinyl- -ester E2, 222 1-Propinyl- -S-ester E2, 222 -S-(2-vinylthio-ethylester) E2, 226... 

Qnecksilber 2-Hydroxy-3-phenyl-propyl- -chlorid XIII/2b, 136, 140... 

Benzene, (2-chloro-1,1-dimethylethyl)- (p-Chloro-a,a-dimethyl)ethylbenzene (p-Chloro-t-butyl)benzene (2-Chloro-1,1-dimethylethyl)benzene p,p-Dimethylphen-ethyl chloride EINECS 208-197-7 2-Methyl-2-phenyl-propyl chloride Neophyl chloride NSC 54159. Liquid bp = 223 , bpi8 = 105" very soluble in EtOH, EtzO, MezCO, CeHe. 

Phenyl-2-propenoic acid, e279 3-Phenyl-2-propen-l-ol, c282 3-Phenyl-2-propenoyl chloride, c280 3-Phenylpropyl alcohol, pi46 Phenyl propyl ketone, b619... 

Divalent sulfur is a poison for most noble metal catalysts so that catalytic hydrogenation of sulfur-containing compounds poses serious problems (p. 10). However, allyl phenyl sulfide was hydrogenated over tris trisphenyl-phosphine)rhodium chloride in benzene to give 93% yield of phenyl propyl sulfide [674. ... 

Experiment 6.121 BUTYROPHENONE (Phenyl propyl ketone-use of the acyl chloride)... 

To a solution of 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol in THF was dissolved in THF (1 mL) and DMF (1 mL) at -40°C was added diisopropylethylamine (2.2 mmol) and then methanesulfonyl chloride (2.2 mmol). The mixture was stirred 2 hours with slow warming to -30°C. The methyl l-(thiomethyl)cyclopropaneacetate (2.3 mmol) was added to the cloudy reaction mixture followed by dropwise addition of potassium tert-butoxide/THF solution (4.4 mmol). The reaction mixture was stirred at -30°C for 3.5 hours before quenching it with 25% aq NH40Ac. Extraction with EtOAc, washing the organic layer with brine and evaporation of the solvents left a residue that was purified by flash chromatography (5%-10% EtOAc in toluene) giving 658 mg (53%) of methyl l ((((R) (3 (2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)propyl)thio)methyl)cyclopropaneacetate. 

Thiophosphonigsaure-ester-halogenide unterliegen der Michaelis Arbuzov-Reaktion mit Alkylhalogeniden866, z.B. kann so Phenyl-propyl-thiophosphinsaure-chlorid in 62%iger Ausbeute gewonnen werden ... 

Phenyl-propyl- XII/1, 232 Phenyl-(1,1,2,3-tetramethyl-butyl)- E2, 146 Phenyl-2-thienyl- -ethylester E2, 201 Phenyl-trichlormethyl- XII/1, 232 Phenyl-trichlormethyl- -methylester XII/1, 256 Phenyl-trichlormethyl- -propylester XII/1, 256 Phcnyl-(2-triethylstannyl-ethyl)- E2, 170 Phenyl-triphenylmethyl- -chlorid E2, 154 Phenyl-triphenylmethyl- -(2-mcthyl-propylcster) Xll/1, 256... 

It is interesting to note that related elimination studies (Sera et al., 1973 Alunni et al., 1974), using different substrates (phenylsulfonyl acetates and l-phenyl-2-propyl chloride), have revealed contrasting... 

This two-step sequence can synthesize many alkylbenzenes that are impossible to make by direct alkylation. For example, we saw earlier that n-propylbenzene cannot be made by Friedel-Crafts alkylation. Benzene reacts with n-propyl chloride and AICI3 to give isopropylbenzene, together with some diisopropylbenzene. In the acylation, however, benzene reacts with propanoyl chloride and A1C13 to give ethyl phenyl ketone (propiophenone), which is easily reduced to n-propylbenzene. 

CMCs of these polyfluorinated surfactants are of the order of 10 5 m.47 Plots of the observed H chemical shifts versus surfactant concentration of cetyl trimethyl ammonium chloride, cetyl pyridinium chloride, cetyl dimethyl phenyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride, cetyl dimethy 1-2-phenyl ethyl ammonium chloride, and cetyl dimethyl-3-phenyl propyl ammonium chloride, are sigmoidal and were fitted to a model based on the mass action. The H chemical shift-based CMC values are in excellent agreement with those determined by the surface tension method.48 The micellization processes of dodecyl trimethyl ammonium halides (chloride and bromide) studied by calorimetric titration show different behaviors at 298 K. However, these disappear at 313 K, while the results measured by the chemical shift versus surfactant concentration do not show this difference.49 The CMC of 3-aminopropyl triethoxy silane in toluene is ca. 0.47m, measured by H and l3C chemical shifts.50 The CMC of optically active potassium A -n-dodecanoyl alaminate measured by H and l3C chemical shifts is lower (11-15 him) in D20 than that in a mixed solvent of 1,4-dioxane and D20 (19mM).-51 The H chemical shift shows that the CMC of resorcinol-type calix[4] phosphoric esters having four alkyl side-chains, [4]Ar 5P-R-n, is insensitive to the length of the side-chains, n.52 The CMC values of a family of surfactants, the sodium cyclohexyl alkanoates, with different lengths of the alkanoate side-chains, were obtained from 13C chemical-shift measurements. The results show that these amphiphiles have high CMCs (0.12-1.02 m).-53... 

Mcthyl-3-(2-oxo-propyl)- -chlorid 350 3-Methyl-2-phenyl- -iodid 349 3-Methyl-4-phenyl- -perchlorat 193 3-Methyl-5-sulfonato- 226... 

Addition of nitrosyl chloride also does not give single products.30 However, it seems to be of practical use for esters of unsaturated alcohols for instance, Pfleger and Landauer31 obtained 65% of 3-chloro-2-(hydroxyimino)-3-phenyl-propyl acetate in this way from cinnamyl acetate ... 

MMTS MsOH NBS NHMDS NMP NMR PPb Ph Pr PTC rt TBDMS Tf THF THP TLC TMEDA TMS TMSOTf Tol TOMAC Ts TsOH UDP methyl methylthiomethyl sulfoxide (=FAMSO) methanesulfonic acid N-bromosuccinimide sodium hexamethyldisililazide /V-methyl-2-pyrrolidone nuclear magnetic resonance parts per billion phenyl propyl Phase transfer catalysis room temperature t-butyldimethylsilyl triflatc (trifluoromethanesulfonate) tetrahydrofuran 2-tetrahydro-2//-pyran-2-yl thin-layer chromatography /V./V./V /V -tetramethylethylenediamine trimethylsilyl trimethylsilyl triflate p-tolyl trioctylmethylammonium chloride tosyl p-toluenesulfonic acid ultrasonically dispersed potassium... 

Figure 24. Stereoselective synthesis of (lS,2/ )-l-aminoindanol and indinavir sulfate. Reagents a, NaOCl, 4-(3-phenyl propyl)-pyridinc-/V-oxidc b, oleum, MeCN c, H20 d, tartaric acid e, NH3, MeOH f, PhCOCl, NaOH g, 80% H2S04 h, LHMDS, allylbromide i, NBS, Nal j, H20, NaHCO, k, MeONa I, MeOH m, HQ g n, 3-picolyl chloride o, H2S04.

Cinnamic acid, 3-phenyl propyl ester. See 3-Phenylpropyl cinnamate Cinnamic alcohol. SeeCinnamyl alcohol, Cinnamic aldehyde. See Cinnamal Cinnamic aldehyde ethylene glycol acetal. See Cinnamaldehyde ethylene glycol acetal Cinnamic chloride. See Cinnamoyl chloride Cinnamol. See Styrene Cinnamomum camphora. See Camphor Cinnamomum camphora oil. See Camphor (Cinnamomum camphora) oii Cinnamomum cassia. See Cinnamon (Cinnamomum cassia) extract Cinnamon (Cinnamomum cassia) Cinnamon (Cinnamomum cassia) oii... 

Hydroxymethyl- -methylester 601 2-[2-(2-Hydroxy-phenyl)-athyIj- 767 -[l-hydroxy-propyl-(2)-amid] 212 -isopropylester-isopropylimid 359 2-Jod- 160 2-Jod- -chlorid 186... 

PHENYL-METHOXY)CARBONYL] -L-PROLYL]-GLYCYL]-, ETHYL ESTER [57621-06-41,56,88 Grignard reagent, 3-(dimethylamino)propyl-magnesium chloride, 55, 127 methylmagnesium bromide, 55, 63... 

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