Propyl chlorides

The formation of isopropylbenzene when n-propyl chloride is employed as the alkylating agent is readily accounted for by the isomerisation of the alkyl carbonium (or alkylium) ion ... 

Chloropropane Propyl chloride 198 C4H7CI Methyl mercaptan Methanethiol 181 CH4S... 

Ailyl chloride [107-05-1] M 76.5, b 45.1", d 0.939, n 1.4130. Likely impurities include 2-chloropropene, propyl chloride, /-propyl chloride, 3,3-dichloropropane, 1,2-dichloropropane and 1,3-dichloropropane. Purified by washing with cone HCl, then with Na2C03 soln, drying with CaCl2, and distn through an efficient column [Oae and Vanderwerf J Am Chem Soc 75 2724 1953], LACHRYMATOR, TOXIC. 

The reaction rates of toluene and benzene with i-propyl chloride in nitromethane fit a third-order rate law ... 

Compare the results given below for the alkylation of p-xylene under a variety of conditions. Explain the reasons for the variation in product composition with temperature and with the use of n- versus i-propyl chloride. 

Calculate energies for reaction of 2-methyl-2-propyl chloride (to 2-methyl-2-propyl cation), 2-phenyl-2-propyl chloride (to 2-phenyl-2-propyl cation) mdphenyl chloride (to phenyl cation). (The energy of chloride is given at right.) Assuming that reaction (1) is normal , what is the effect of a benzene ring Does it facilitate or hinder loss of chloride ... 

Phthalic anhydride is reacted with phenylacetic acid to form 3-benzylidenephthalide which is then hydrogenated to 2-phenethylbenzoic acid. Conversion to the acid chloride followed by intramolecular dehydrochlorination yields the ketone, 5H-dibenzo[a,d] cyclohepten-5-one. The ketone undergoes a Grignard reaction with 3-(dimethylamino)propyl chloride to give 5-(7-dimethylaminopropylidene)-5H-dibenzo[a,d] cycloheptene. 

Ethy I-p-hydroxy benzoate Cyclohexyl bromide 3-(2 -Methylplperidino)propyl chloride... 

A suspension of 4 parts NaNH in 50 parts by volume of absolute benzene are then added dropwise at 50° to 60°C after which the mixture is boiled for an hour under reflux. 13 parts of 3-dimethylamino n-propyl chloride are then added dropwise at 40° to 50°C and the mixture is boiled for 10 hours under reflux. After cooling, the benzene solution is thoroughly washed with water, whereupon the basic constituents are extracted with dilute hydrochloric acid. 

Amitriptylin oxide 3-(Dimethylamino) propyl chloride Amitriptyline HCI Ch/orprothixene Clomipramine Cyclobenzaprine Imipramine HCI Oxetorone fumarate Prothipendyl HCI... 

Scheme 5.1-49 The alkylation of benzene with methyl chloride or n-propyl chloride in an ionic liquid.

Potassium hydroxide, alcoholic, 7, 77 Potassium iodide, 4, 37 7, 14, 58 Potassium permanganate, 7, 18 8, 68 Potassium Phthalimide, 7, 8, 78 Potassium sulfate, 6, 2 Prest-o-lite tank, 8, 10 Propane-1, 1, 2, 3-Tetracarboxyuc Ester (Ethyl), 4, 29, 77 m-Propylbenzene, 4, 59 t 50-Propyl chloride, 5, 28 i-Propy] chloride, 5, 28... 

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