Peri-implantitis

Norowski PA Jr, Bumgardner Joel D (2009) Biomaterial and antibiotic strategies for peri-implantitis a review. J Biomed Mater Res B Appl Biomater 88 530-543... 

Sorsa T, Mantyla P, Ronka H, KaUio P, Kalhs GB, Lnndqvist C, Kinane DF, Salo T, Golnb LM, Teronen O, Tikanoja S. Scientific basis of a matrix metaUoproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease. Ann NY Acad Sci 1999 878 130-40. 

Mouse embryonic peri-implantation assay MEPA Survival on day 8 hatched blastocyst stage Peri-implantation development from zygote to blastocyst... 

Heitz-Mayfield, L.J. and Lang, N.P. (2004) Antimicrobial treatment of peri-implant diseases. International Journal of Oral Maxillofacial Implants, 19 (Suppl), 128-139. 

The hES cells were shown to fulfill aU the criteria defining embryonic stem cells [28, 29], namely derivation from the pre-or peri-implantation embryo, prolonged undifferentiated proliferation under special conditions, and the capacity to form deri-... 

Thorfve, A., Lindahl, C., Xia, W., Igawa, I<., Lindahl, A., Thomsen, P., Palmquist, A., and Tengvall, P. (2014) Hydroxyapatite coating affects the Wnt signaling pathway during peri-implant healing in vivo. Acta Biomater., 10 (3), 1451-1462. 

Figure 7.78 Histological haematoxylin/ eosin-stained tibia diaphysis peri-implant sections of rabbit, (a) Uncoated (group I), showing cancellous bone (1) and well-developed marrow spaces. Bone lamellae (2) are lined by osteoblasts. Marrow cavities contain adipose tissue (3). (b) Neo-formation of...

The ability of biomimetically deposited calcium phosphate coatings to foster peri-implant bone formation was tested and positively answered by many studies involving a dog model (for example Schliephake et al., 2003 Schliephake et al., 2006 Schliephake et al., 2009 Coelho et al., 2009). 

Rossant, J. Lineage development and polar asymmetries in the peri-implantation mouse blastocyst. Semin Cell Dev Biol 15 (2004) 573-81. 

Kimber SJ, Lindenberg S, Lundblad A. Distribution of some Galbl-3(4) GlcNAc related carbohydrate antigens on the mouse uterine epithelium in relation to the peri-implantation period. J Reprod Imm 1988 12 297-313. 

Rinkenbeiger JL, Homing S, Klocke B, Roth K, Korsmeyer SJ Mcl-l deficiency results in peri-implantation embryonic lethality. Genes Dev 2000 14 23-27. 

Rappolee DA, Patel Y, Jacobson K. 1998. Expression of fibroblast growth factor receptors in peri-implantation mouse embryos. Mol Reprod Dev 51(3) 254-264. 

Bollen CM, Papaioanno W, Van EJ, et al. The influence of abutment surface roughness on plaque accumulation and peri-implant mucositis. Clin Oral Implants Res September 1996 7(3) 201-11. 

Scarano, A Orsini, G Pecora, G lezzi, G PeiTotti, V Piattelli, A. Peri-implant bone regeneration with calcium sulfate a light and transmission electron microscopy case report. Implant Dentistry, 2007,16, 195-203. 

Fig. 13.14. Peri-implantitis, lucency surrounding implants several weeks after surgery...

In two cases exposure to titanium in dental implants caused reactive lesions in the peri-implant mucosa, diagnosed as epulis, in which metal-like particles were observed histologically [87" ]. One involved a pyogenic granuloma and the other a peripheral giant cell granuloma. 

Olmedo DG, Paparella ML, Brandizzi D, Cabrini RL. Reactive lesions of peri-implant mucosa associated with titanium dental implants a report of 2 cases. Int J Oral Maxillofac Surg 2010 39(5) 503-7. 

Meraw, S.J., Reeve, C.M., Lohse, C.M., and Sioussat, T.M. Treatment of peri-implant defects with combination growth factor cement. /. Periodontal. 71 8 13,2000. 

Witte, E, Ulrich, H., Palm, C. Willbold, E (2007a) Biodegradable magnesium scaffolds Part II peri-implant bone remodeling. J Biomed Mater Res A, 81, 757-65. 

Crotti TN, Smith MD, Findlay DM, Zreiqat H, Ahern MJ, Weedon H, et al. Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss expression of receptor activator NFkappaB, RANK ligand and osteoprotegerin. Biomaterials 2004 Febiuaiy 25(4) 565-73. 

Keywords— Metal implant, bio-corrosion, osteoclast, immune cells, peri-implant inflammation. 

Osteoclasts play a major role in bio-corrosion of orthopedic metal implants. Implant-derived metal ions enhance osteoclastic recruitment, maturation, survival and function. The metal ions also induce a peri-implant inflammation with accumulation of various immune cells. The metal ions form complexes with cellular proteins that become new antigens inducing allergenic reactions where T-lymphocytes play an essential role. Those immune cells produce various inflammatory cytokines that cause inflammation and pain. In addition, T-lymphocytes secrete RANK-L, an essential factor for osteoclast functions. Finally, the described mechanisms are probably responsible for a vicious cycle with enhanced peri-implant inflammation and pain, as well as enhanced osteoclastic bio-corrosion and peri-implant bone resorption culminating in implant loosening (Figure 3). 

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