Partition coefficient, chromatographic

Ong, S. Liu, H. Qiu, X. Bhat, G. Pidgeon, C., Membrane partition coefficients chromatographically measured using immobilized artificial membrane surfaces, Anal. Chem. 67, 755-762 (1995). 

Menges, R.A., Bertrand, G.L., and Armstrong, D.W. Direct measurement of octanol-water partition coefficient chromatograph with a back-flushing technique, / Liq. Chromatogr., 13(15) 3061-3077, 1990. 

Yalkowsky and Banerjee have pubhshed an extensive review of methods for estimating aqueous water solubility of organic compounds. Many methods have been developed based on measured properties such as partition coefficients, chromatographic parameters, and activity coefficients. " Purely in silico methods are based on LFER, and a variety of geometric, electronic, and topological molecular descriptors. ... 

In such series the continuous growth of an alkyl chain or of methylene units increases the hydrophobic part of the molecule. Various physicochemical parameters, such as solubility in water, partition coefficients, chromatographic Rf values, and critical micellar concentration, are precisely governed by the same fundamental property the hydrophobic character. 

Methods based on experimental physico-chemical properties such as partition coefficients, chromatographic retention, boiling point, and molecular volume. 

HSCCC is attracting attention based on its high separation scale, 100% recovery of sample, and mild operating conditions. It is a chromatographic separation process based on the partition coefficients of different analytes in two immiscible solvent systems (mobile phase and stationary phase) subjected to a centrifugal acceleration field. 

The net retention volume and the specific retention volume, defined in Table 1.1, are important parameters for determining physicochemical constants from gas chromatographic data [9,10,32]. The free energy, enthalpy, and. entropy of nixing or solution, and the infinite dilution solute activity coefficients can be determined from retention measurements. Measurements are usually made at infinite dilution (Henry s law region) in which the value of the activity coefficient (also the gas-liquid partition coefficient) can be assumed to have a constant value. At infinite dilution the solute molecules are not sufficiently close to exert any mutual attractions, and the environment of each may be considered to consist entirely of solvent molecules. The activity... 

Barbato, F. La Rotonda, M. I. Quaglia, E, Interactions of nonsteroidal antiinflammatory drugs with phospholipids comparison between octanol/buffer partition coefficients and chromatographic indexes on immobilized artificial membranes, J. Pharm. Sci. 86, 225-229 (1997). 

Miyake, K. Kitaura, F. Mizuno, N., Phosphatidylcholine-coated silica as a useful stationary phase for high-performance liquid chromatographic determination of partition coefficients between octanol and water, J. Chromatogr. 389, 47-56 (1987). 

El Tayar, N. Tsai, R.-S. Vallat, P. Altomare, C. Testa, B., Measurement of partition coefficients by various centrifugal partition chromatographic techniques. A comparative evaluation, J. Chromatogr. 556, 181-194 (1991). 

Measurements of gas chromatographic retention time are often used as a fast and easy method of estimating vapor pressure. These estimated pressures are related to the gas/substrate partition coefficient, which can be regarded as a ratio of solubility of the substance in the gas to that in the substrate, both solubilities being of the substance in the liquid state. As a result the estimated vapor pressures are of the liquid state. To obtain the solid vapor pressure requires multiplication by the fugacity ratio. It is important to establish if the estimated and reported property is of the vapor or liquid. 

Burkhard, L. P, Kuehl, D. W., Veith G. D. (1985c) Evaluation of reversed phase liquid chromatograph/mass spectrometry for estimation of n-octanol/water partition coefficients of organic chemicals. Chemosphere 14, 1551-1560. 

Burnett, M. G. (1963) Determination of partition coefficients in infinite dilution by the gas chromatographic analysis of the vapor above dilute solutions. Anal. Chem. 35, 1567-1570. 

Garst, J.E. (1984) Accurate, wide-range, automated, high-performance chromatographic method for the estimation of octanol/water partition coefficients. II Equilibrium in partition coefficient measurements, additivity of substituent constants, and correlation of biological data. J. Pharm. Sci. 73, 1623-1629. 

Rapaport, R. A., Eisenreich, S. J. (1984) Chromatographic determination of octanol-water partition coefficients (K, )W s) for 58 polychlorinated biphenyl congeners. Environ. Sci. Technol. 18, 163-170. 

Su,Y., Lei, D.L. Daly, G.,Wania, F. (2002) Determination of octanol-air partition coefficient (KqA) values for chlorobenzenes and polychlorinated naphthalenes from gas chromatographic retention times. J. Chem. Eng. Data, 47, 449 455. 

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