Pantoprazole infection

Proton pump inhibitors (PPIs), such as omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole, are commonly prescribed to treat symptoms of heartburn, acid reflux, chest pain, dyspepsia, and chronic cough. PPIs inhibit the transfer of protons into the stomach lumen. Pharmacological acid suppression is thus used to treat gastroesophageal reflux disease (GERD) and esophagitis, peptic ulcers, and Helicobacter pylori infection as well as to prevent ulcer development with concurrent nonsteroidal anti-inflammatory drug use. 

Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor, and was developed for the treatment of acid-related gastrointestinal disorders. As with other drugs of its class (e. g. omeprazol or lansoprazole), pantoprazole reduces gastric acid secretion through inhibition of the portion on the gastric parietal cell. In combination with other drugs, pantoprazole can be used for the initial treatment of H. Pylori infection [1],... 

Svoboda, P., Kantorova, I., Ochmann, J., Doubek, J., Kozumplik, L., and Marsova, J. (1997). Pantoprazole-based dual and triple therapy for the eradication of Helicobacter pylori infection A randomized controlled trial. Hepatogastroenterology 44, 886-890. 

Systematic reviews Laboratory and chnical evidence suggest that the increase in gastric pH caused by proton pump inhibitors may be linked to increased bacterial colonization of the stomach and may predispose patients to an increased risk of respiratory infections. The association of proton pump inhibitors (esomeprazole, rabeprazole, pantoprazole, and omeprazole) with respiratory infections has been studied in a systematic review of seven studies, four of which showed a trend towards an association, although most of the studies failed to show a significant correlation [54 ]. 

Holtmann G, Cain C, Malfertheiner P. Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazole. Gastroenterology 1999 117 11-16. 

Suerbaum S, keying H, Klemm K et al (1991) Antibacterial activity of pantoprazole and omeprazole against Helicobacter pylori. Eur J Clin Microbiol Infect Dis 10 92-93... 

Adamek Szymanski C, Pfaffenbach B, et al (1995) Short term triple therapy with pantoprazole, clarithromycin and metronidazole for the healing of Helicobacter pylori infection. Dtsch Med Wochenschr 120 358-360... 

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