Pantoprazole

Intravenous infusion is 40 mg given once daily for 7 to 10 days 

Patients should be cautioned that tablets should not be split, chewed or crushed. 

Injection admixtures should be administered intravenously, using the inline filter provided, over a period of approximately 15 minutes at a rate not greater than 3 mg/min 

JJ proximal and distal tubules, as as shown by marked water reduc- 

E well as in the loop of Henle tion offree-waterclearanceduring 

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M. Tanaka and H. Yamazaki, Dkect detemination of pantoprazole enantiomers in human serum by reversed-phase liigh peifomance liquid chi omatography using a cellulose-based cliiral stationaiy phase and column-switching system as a sample cleanup procedure , Aim/. Chem. 68 1513-1516(1996). 

Pantoprazole and tenatoprazole bind only to both the cysteines in M5/M6, cysteine 813 and 822, and lansoprazole binds to cysteine 321 in M3/M4 and to cysteine 813 in M5/M6, and cysteine 892 in M7/M8. These data suggest that, of the 28 cysteines in the a-subunit, only the cysteines present in the M5/M6... 

The proton pump inhibitors are contraindicated in patients who have hypersensitivity to any of the drags. Omeprazole (Pregnancy Category C) and lansoprazole, rabeprazole, and pantoprazole (Pregnancy Category B) are contraindicated during pregnancy and lactation. The proton pump inhibitors are used cautiously in older adults and in patients with hepatic impairment. 

CjjH(,F2N20S 97963-62-7) see Pantoprazole sodium 4-(difluoromethoxy)-2-nitrobenzenamine (C7H(,F2N203, 97963-76-3) see Pantoprazole sodium A -[4-(difluoromethoxy)phenyl]acetamide (0)HyF2N02 22236-11-9) see Pantoprazole sodium 2-(difluoromethoxy)-l,l,l-trifiuoroethane (C3H3F5O 1885-48-9) see Isoflurane (5)-9,10-difluoro-3-methyI-7-oxo-2,3-dihydro-7/f-pyrb do[l,23-d ]-Iy4 benzoxazine-6-carboxylic acid (C,3Hyp2N04 100986-89-H) see Levofloxacin... 

C2jH27N303 71987-57-0) see Oxypertine 3,4 dimethoxy-2-methylpy ridine 1 -oxide (CjHiiNO, 72830-07-0) see Pantoprazole sodium... 

C3H5KOS2 140-89-6) see Cefaclor Omeprazole Pantoprazole sodium Protizinic acid Pyritinol potassium hexachloroplatinate(IV)... 

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... 

Raffin, R. P., Jornada, D. S., Re, M. L, Pohimann, A. R. Guterres, S. S. (2006). Sodium pantoprazole-loaded enteric microparticles prepared by spray drying Effect of the scale of production and process validation. International Journal of Pharmaceutics, Vol. 324,1, (October 2006), pp. (10-18), ISSN 0378-5173... 

Omeprazole 20-40 mg enterally daily ° Esomeprazole 20-40 mg enterally daily or ql2h ° Lansoprazole 30 mg enterally or IV daily ° Pantoprazole 40 mg enterally or IV daily or 12h ° Rabeprazole 20 mg enterally daily... 

H2 receptor antagonists (Cimetidine, famotidine, nizatidine, ranitidine) Proton pump inhibitors Lansoprazole Omeprazole Pantoprazole Rabeprazole... 

PPIs (taken once daily) for 4-8 weeks - Esomeprazole 20 mg - Lansoprazole 1 5-30 mg - Omeprazole 20 mg - Pantoprazole 40 mg - Rabeprazole 20 mg therapy. 

Comparable daily doses of PPIs are omeprazole 20 mg = esomeprazole 20 mg = lansoprazole 30 mg = rabeprazole 20 mg = pantoprazole 40 mg. The PPIs degrade in acidic environments and are therefore formulated in delayed-release capsules or tablets.16 Lansoprazole, esomeprazole, and omeprazole contain enteric-coated (pH-sensitive) granules in a capsule form. For patients unable to swallow the capsule or in pediatric patients, the contents of the capsule can be mixed in applesauce or placed in orange juice. If a patient has a nasogastric tube, the contents of an omeprazole capsule can be... 

Pantoprazole, lansoprazole, and esomeprazole are available in intravenous formulations, which offer an alternative route for patients unable to take oral medications. The intravenous product is not more effective than the oral forms and is significantly more expensive. 

Welage LS, Berardi RR. Evaluation of omeprazole, lansoprazole, pantoprazole, and rabeprazole in the treatment of acid-related disorders. J Am Pharm Assoc 2000 40 52-62. 

Atorvastatin 40 mg PO once daily Hydrochlorothiazide 25 mg PO once daily Amlodipine 5 mg PO once daily Lantus insulin 30 units per day Multivitamin 1 tablet daily Pantoprazole 40 mg PO once daily Maalox 15 mL PO 4 times daily as needed for heartburn/stomach upset... 

The patient returns for a follow-up visit at your clinic 6 weeks later. He reports no pain or swelling in the joints affected previously. The emergency room doctor had instructed him to stop the chlorthalidone, so he is currently taking only pantoprazole. 

Xie, Z. Y., Huang, H.H. andZhong, D.F. (2005) Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. Xenobiotica The Fate of Foreign Compounds in Biological Systems, 35, 461-411. 

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