Accelerated healing

The mechanism by which sucralfate accelerates healing of duodenal ulcers has not been determined. It does not have significant antisecretory, acid neutralizing activity or direct stimulation of ulcer healing. It is known that the mechanism is local rather than systemic. Binding of pepsin or bile salts may contribute to its effect. It is indicated for the short-term therapy of active duodenal ulcers and for maintenance at reduced dosage. 

Dmgs are employed with the following therapeutic aims (1) to relieve pain (2) to accelerate healing and (3) to prevent ulcer recurrence. Therapeutic approaches are threefold (a) to reduce aggressive forces by lowering H+ output (b) to increase protective forces by means of mucoprotectants and (c) to eradicate Helicobacter pylori. 

Meyer-Ingold, W. (1993). Wound therapy growth factors as agents to promote healing. Trends Biotechnol. 11, 387-392. Mustoe, T. et al. (1987). Accelerated healing of incisional wounds in rats induced by transforming growth factor type fl. Science 347, 1333-1336. 

Acyclovir reduces the extent and duration of VZV lesions in adults and children, although higher doses are required than for the treatment of HSV infection. Although not recommended for the routine treatment of uncomplicated varicella in children, acyclovir may be used for chickenpox treatment and prophylaxis in high-risk individuals. Acyclovir accelerates healing in patients with herpes zoster (shingles), but it does not affect postherpetic neuralgia. 

Sucralfate is a basic aluminium salt of sucrose, a complex of sucrose octasulphate and aluminium hydroxide. At acid pH (<4), it forms a very sticky gel polymer, which adheres to epithelial cells and the base of ulcer craters. It has little or no antacid activity, but more importantly has a major cytoprotective action, both protecting the mucosa from damaging influences and also causing accelerated healing. It appears to work through a number of relatively poorly understood mechanisms, enhancing several gastric and duodenal protective mechanisms—different actions may be related to its chemistry as an aluminium salt, and to the sucrose octasulphate component. 

Accelerated healing of severely dr y skin, cracked skin, and minor burns To reduce skin wound healing time and risk of infection Follow-up skin treatment for patients undergoing radiation therapy or otherdrying/burning medical therapies... 

T. Odoriba, H. Tozaki, A. Yamamoto, A. Terabe, T. Suzuki, and S. Muranishi, Colon delivery of anti-inflammatory drugs accelerates healing of TNBS induced-colitis in rats, Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24 345-346 (1997). 

Chitin s properties as a tough and strong material make it favourable as surgical thread. Additionally, its biodegradibility means it wears away with time as the wound heals. Moreover, chitin has some unusual properties that accelerate healing of wounds in humans. Chitin has even been used as a stand-alone wound-healing agent. 

Therapy for herpes zoster should be aimed at accelerating healing, limiting the severity and duration of acute and chronic pain and reducing any complications associated with the infection. In patients who are immunocompromised, therapy should also be aimed at reducing the risk of viral dissemination. Acyclovir, valacyclovir, and famciclovir are all used in the United States for the treatment of herpes zoster. Acyclovir is approved in the U.S. for the treatment of both chickenpox and herpes zoster in the normal host. Oral acyclovir therapy in normal children, adolescents, and adults shortens the duration of lesion formation by about a day, reduces the total number of new lesions by abont 25%, and reduces many of the symptoms in abont a third of patients (Gnann and Whitley, 2002 Snoeck et al., 1999). 

To test whether omeprazole accelerates healing of standardized gastroduodenal lesions in the presence of diclofenac, 12 healthy volunteers took consecutive 2-week courses of omeprazole 40 mg/day or placebo, with diclofenac given in the second week of each course, in a double-blind, crossover study (3). Omeprazole did not accelerate the healing of pre-existing mucosal lesions or prevent the development of small diclofenac-induced mucosal lesions. Omeprazole increased serum gastrin in all subjects. 

The post-peel mask cream should be applied twice 50% immediately after the peel and the remaining 50% the morning of the first day after the peel. It stimulates the skin and breaks the vicious oxidative circle inflammation free radicals , and accelerates healing time. It also helps to limit the vicious inflammatory circle that follows any medium-depth peel and coimters post-peel pigmentary changes. 

Neural stimulators are battery-powered electrodes useful for several treatments—pain, some mental disorders, and accelerated healing of bone fractures, for example. These systems have power requirements up to a hundred times that of dispensers. 

Intravenous pantoprazole or lansoprazole clearly is the preferred therapy in patients with acute bleeding ulcers. The theoretical benefit of maximal acid suppression in this setting is to accelerate healing of the underlying ulcer. In addition, a higher gastric pH enhances clot formation and retards clot dissolution. 

A small molecule that polymerizes in stomach acid and coats the ulcer bed, resulting in accelerated healing and reduction of symptoms... 

Cadexomer Iodine is a hydrophilic, modified staurch polymer containing 0.9% iodine within the helical structure it is used in the treatment of decubitus and venous leg ulcers. Applied to a wound surface as a powder, it is reported to accelerate healing, stimulate granulation, clean the ulcer surface, relieve pain and reduce bacterial counts. 

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