P53 gene mutation

Behn M., Schuermann M. Sensitive detection of p53 gene mutations by a mutant-enriched PCR-SSCP technique. Nucleic Acids Res. 1998 26 1356-1358. 

Sidransky, D., Eschenbach, A. V., Tsai, Y. C., Jones, P., Summerhayes, I. etal.. Identification of p53 gene mutations in bladder cancers and urine samples. Science 252, 706-709 (1991). 

Maesawa, C Tamura, G Suzuki, Y., Ishida, K., Saito, K., and Satodate, R. (1992) Sensitive detection of p53 gene mutations in esophageal endoscopic biopsy specimens by cell sorting combined with polymerase chain reaction single-strand conformation polymorphism analysis. Jpn. J. Cancer Res. 83, 1253-1256. 

Jenkins et alf" examined the formation of mutations in the p53 gene in oesophageal cell lines following treatment with deoxycholic acid for 24 h. The authors demonstrated an increased frequency of GC to AT mutations in KYSE-30 cells at neutral pH. The lARC TP53 Mutation Database compiles (http //www-p53.iarc.fr/index.html) p53 gene mutations identified in human... 

Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, Perng RP (1996) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 56 206-209 Oberall F, Oberhuber H, Maly K, Zaknun J, Demuth L, Grunicke HH (1991) Hexade-cylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res 51 807-812... 

Saed G, Ladin D, Olson J (1998) Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Arch Dermatol 134 963-967... 

Bian, Y.-S., Osterheld, M.-C., Bosman, F. T., Benhattar, J., and Fontolliet, C. 2001. p53 gene mutation and protein accumulation during neoplastic progression in Barrett s esophagus. Mod. Pathol. 74 397-403. 

HI8. Hernandez, L., Fest, T., Cazorla, M., Teruya-Feldstein, J., Bosch, F., Peinado, M. A., Piris, M. A., Montserrat, E., Cardesa, A., Jaffe, E. S., Campo, E., and Raffold, M., p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood. 87,3351-3359 (1996). 

Righetti, S. C., Torre, G. D., Pilotti, S Menard, S Ottone, F., Colnaghi, M. I., Pierotti, M. A., Lavarino, C., Comarotti, M., Oriana, S Bohm, S Bresciani, G. L., Spatti, G., and Zunino, F. (1996) a comparative study of p53 gene mutations, protein accumulation and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res. 56, 689-693. 

Spatti, G., and Zunino, F. (1996) A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res. 56, 689-693. 

Bodner, S., Minna, J., Jensen, S., DAmico, D., Carbone, D Mitsudomi, T Fedorko, I., Buchhagen, D., Nau, M., Gazdar, A., andLinnoila, R. (1992) Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene 7, 743-749. 

Top, B., Mooi, W., Kiaver, S., Boerrigter, L., Wisman, P Elbers, U Visser, S and Rodenhuis, S. (1995) Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer. Ini. J. Cancer. 64,83-91. 

S. (1996) Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value. Proc. Natl. Acad. Sci. USA 93, 1093-1096. 

Blaszyk, H., Hartmann, A., Schroeder, J., McGovern, R., Soinmer, S., and Kovach, J. (1995) Rapid and efficient screening for p53 gene mutations by dideoxy fingerprinting. BioTechniques 18, 256-260. 

Puisieux A, Lhn Sj Groopman J, Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res 1991 51 6185-9. 

Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, vanTuinen P, Ledbetter DH, Barker DF, Nakamura Y, et al (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244 217-221... 

Tsai CM, Chang KT, Wu LH, et al. Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 1996 56 206-209. 

Hernandez L, Best T, Cazorla M, et al. p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood. 1996 87(8) 3351-3359. 

Cesarman E, Inghirami G, Chadburn A, et al. High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma. Am J Pathol. 1993 143(3) 845-856. 

Tateyama H, Eimoto T, Tada T, et al. p53 protein expression and p53 gene mutation in thymic epithelial tumors An immunohistochemical and DNA sequencing study. Am J Clin Pathol. 1995 104 375-381. 

P53 Normal p53 protein has an extremely short half-life and is found in small quantities inside cells. As such, p53 cannot be detected in normal cells using immuno-histochemistry. The p53 protein from abnormal p53 genes has a longer half-life than normal p53 protein, builds up inside cells, and can be detected with anti-p53 antibodies. In theory, p53 overexpression, as a surrogate marker for p53 gene mutations, is an immunohis-tochemical test for neoplasia (dysplasia). However, this is not the case in practice because correlation between staining and gene abnormalities is not precise. ... 

Pell ata NS, Sessa F, Renault B, et ak K-ras and p53 gene mutations in pancreatic cancer ductal and nonductal tumors progress through different genetic lesions. Cancer Res. 1994 54 1556-1560. 

Fujimoto K, Yamada Y, Okajima E, et al. Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res. 1992 52 1393. 

Miyamoto H, Kubota Y, Shuin T, et al. Analyses of p53 gene mutations in primary human bladder cancer. Oncol Res. 1993 5 245. 

Tashiro H, Isacson C, Levine R, et al. p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Am J Pathol. 1997 150 177-185. 

Gao JP, Uchida T, Wang C, et al. Relationship between p53 gene mutation and protein expression Glinical significance in transitional cell carcinoma of the bladder. Ini J Oncol. 2000 16 469-475. 

Can we predict solar ultraviolet radiation as the causal event in human tumors by analyzing the mutation spectra of the p53 gene Mutat. Res., 307, 375-386. 

T. Soussi, K. Dehouche, C. Beroud, p53 website and analysis of p53 gene mutations in human cancer forging a link between epidemiology and carcinogenesis, Hum. Mutat. 2000, 15, 105-213. 

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