Mutational spectra

Oiler, A.R. and Thilly, W.G. (1992). Mutational spectra in human jS-cells. Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene. J. Mol. Biol. 228, 813-826. 

It would be interesting to know if the mutational consequences of DNA lesions in mammalian cells were the same as those which obtain in bacteria. Methods for retrieving and sequencing mutations in mammalian cells and their viruses are now being developed (81-83) If yeast, a eukaryotic microorganism, can be considered representative of higher eukaryotes, then judging from the observations that the mutational spectra for UV-irradiation and 4-nitroquinoline-l-oxide treatment are identical for yeast (84) and bacteria (85), the spectrum of mutations induced by BPDE in mammalian cells could well resemble those induced in E. coli. 

Kundu B, Richardson SD, Granville CA, Shaughnessy DT, Hanley NM, Swartz PD, Richard AM, DeMarini DM (2004) Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TAIOO structure-activity analysis and mutation spectra. Mutat Res 554(l-2) 335-350... 

Cochrane, J.E. Skopek, T.R. (1994) Mutagenicity of butadiene and its epoxide metabolites IL Mutational spectra of butadiene, 1,2-epoxy butene and diepoxy butane at the hprt locus in splenic T cells from exposed B6C3F1 mice. Carcinogenesis, 15. 719-723... 

Veld, C.W. Jansen, J. Zdzienicka, M.Z. Vrieling, H. Van Zeeland, A.A. Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CH09 and its xrccl-deficient derivative EM-C11. Mutat. Res. 1998, 398, 83-92. 

McElroyAE, Bogler A, WeisbaumD, etal. Uptake, metabolism, mutant frequencies and mutational spectra in [lambda] transgenic medaka embryos exposed to benzo[[alpha]] pyrene dosed sediments. Mar Environ Res. 2006 62(Suppl. 1) S273-S277. 

Yadollahi-Farsani, M., Gooderham, N.J., Davies, D.S., and Boobis, A.R. (1996) Mutational spectra of the dietary carcinogen 2-amino-l-methyl-6-phenylimidazo[4,5-k]pyridine (PhIP) at the Chinese hamsters hprt locus. Carcinogenesis, 17, 617-624. 

E., de Boer, J.G., Ushijima, T., Nagao, M and Glickman, B.W. (2000) Interpretation of mutational spectra from different genes analyses of PhIP-induced mutational specificity in the lacl and ell transgenes from colon of Big Blue rats. Mutat. Res., 452, 101-121. 

Can we predict solar ultraviolet radiation as the causal event in human tumors by analyzing the mutation spectra of the p53 gene Mutat. Res., 307, 375-386. 

Daya-Grosjean, L Dumaz, N and Sarasin, A. (1995) The specificity of p53 mutation spectra in sunlight induced human cancers. J. Photochem. Photo-hiol, B 28,115-124. 

Yoon, J.H., Lee, C.S., and Pfeifer, G.P. (2003) Simulated sunlight and benzo[o]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay lack of correspondence to tumor mutation spectra. Carcinogenesis, 24, 113-119. 

Cell cycle arrest and the induction of apoptosis could be functionally related to the activation of p53 and/or the inhibition of cell cycle kinase activity, and research results suggest that flavonoids may be more effective in controlling the growth of tumours with certain mutational spectra [118],... 

Li, B.-H., Ebbert, A., and Bockrath, R. (1999). Transcription-modulated repair in Escherichia coli evident with UV-induced mutation spectra in supF. J. Mol. Biol. 294, 35-48. 

Wang, Y. C., Maher, V. M., Mitchell, D. L., and McCormick, J.J. (1993). Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts. Mol. Cell. Biol. 13, 4276-4283. 

Bichara, M., and Fuchs, R. P. P. (1985). Binding and mutation spectra of the carcinogen N-2-aminofluorene. A correladon between the conformation of the premuta-genic lesion and the mutation specificity. / Mol. BioL 183, 341-351. 

Plou, F.)., and Alcalde, M. (2008) Altering the laccase functionality by in vivo assembly of mutant libraries with different mutational spectra. Proteins, 71, 250-260. 

In 1948, Fries and Kihlman in Sweden reported the production of auxotrophic mutations in the ascomycete Ophiostoma multiannulatum by prolonged immersion of the conidia in solutions of caffeine (0.2%) or theophylline (0.6%). Either treatment yielded about 1% auxotrophs at survival levels of about 0.2% control mutation frequencies were very low. Qualitatively, the results were especially interesting because they showed a difference between the mutational spectra induced by these two purines on the one hand and X-irradiation on the other. This was most striking for inositol requirers, which formed less than 5% of radiation-induced auxotrophs but more than 40% of purine-induced ones. This is one of the rare cases of mutagen specificity for a whole locus or biochemical pathway. Like similar cases that were subsequently reported from the same laboratory, it may rest on selective effects of the plating medium, amplified by the previous treatment of the plated conidia. 

Fig. 11-38 Experimental and simulated (dotted line) mutation spectra at 77K in (a) cw-(CH), and (b) trans- CH) for the samples weakly enriched in pairs. The central peak corresponds to isolated C spins. The deduced bond lengths are r =j=1.44A and r j=1.36Af or trans-(CR. After Reference [440], reproduced with permission.

S.P. Hussain and C.C. Harris, Molecular epidemiology of human cancer contribution of mutation spectra studies of tumor suppressor genes. Cancer Res., 58 (1998) 4023-4037. 

Juedes, M.J. and Wogan, GJ9. (1996). Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells. Mutat. Res. 349,51-61. 

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