Oxygen hemoglobin

Deoxyhemoglobin can bind more carbon dioxide than oxygenated hemoglobin. Therefore, unloading of oxygen in the tissues facilitates loading... 

Goyal, M., Azizi, F., King, S. B., Kim-Shapiro, D. B., Nitric oxide binding to oxygenated hemoglobin under physiological conditions, Biochim. Biophys. Acta 1568 (2001), p. 252-260... 

In addition to oxygen, hemoglobin subunits can also carry carbon dioxide. This is performed by covalent addition of C02 to the N termini of the hemoglobin chains to produce a carbonate structure. Propose reactions for this process utilizing (a) C02 and... 

The most important mechanism that underlies the MR appearance of ICH is the transformation of initially oxygenated hemoglobin into a series of breakdown products (deoxyhemoglobin, methemoglobin, and hemosiderin), that differ in terms of presence and number of unpaired electrons of the heme iron. Hereafter, we will discuss the influence of hemoglobin and its metabolites on T1 and T2 relaxation times. We will also briefly review the effects on MR signals of other factors such as protein concentration, clot formation and retraction, and red blood cell dehydration. 

Carbon monoxide is poisonous because it binds to the Fe of hemoglobin more strongly than does oxygen. Hemoglobin complexed with CO cannot carry O2 from the lungs to the tissues. Without O2 in the tissues for metabolism, cells cannot function, so they die. 

Neither hemoglobin nor oxygenated hemoglobin can leave the liquid phase. Thus the fourth boundary condition states that the flux of total hemoglobin is zero. 

Sigmoidal E ax Model. The sigmoidal E ax model, originally derived based on oxygen-hemoglobin dissociation kinetics,is a generalization of the Emax model. It describes the response vs. drug concentration... 

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