Oxygen-hemoglobin dissociation kinetics

Sigmoidal E ax Model. The sigmoidal E ax model, originally derived based on oxygen-hemoglobin dissociation kinetics,is a generalization of the Emax model. It describes the response vs. drug concentration... 

Hyperbolic shape of the enzyme kinetics curve Most enzymes show Michaelis-Menten kinetics (see p. 58), in which the plot of initial reaction velocity, v0, against substrate concentration [S], is hyperbolic (similar in shape to that of the oxygen-dissociation curve of myoglobin, see p. 29). In contrast, allosteric enzymes frequently show a sigmoidal curve (see p. 62) that is similar in shape to the oxygen-dissociation curve of hemoglobin (see p. 29). 

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