Hemoglobin-based oxygen carriers

Spatial separation of hemoglobin confers many desirable properties to the LEH. Yet, like other hemoglobin-based oxygen carriers, it is not a complete resuscitation fluid for hypovolemic shock. Intervention in severe hemorrhage... [Pg.81]

Pearce LB, Gawryl MS. The pharmacology of tissue oxygenation by biopure s hemoglobin-based oxygen carrier, Hemopure (HBOC-201). Adv Exp Med Biol 2003 530 261. [Pg.82]

Stowell CP. Hemoglobin-based oxygen carriers. Curr Opin Hematol 2002 9 537. [Pg.83]

Fronticelli C, Sato T, Orth C, et al. Bovine hemoglobin as a potential source of hemoglobin-based oxygen carriers crosslinking with bis(2,3-dibromosalycyl)fu-marate. Biochim Biophys Acta 1986 874 76. [Pg.85]

Hughes GS Jr., Francome SF, Antal EJ, et al. Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J Lab Clin Med 1995 126 444. [Pg.91]

The fact that no satisfactory oxygen carrier has reached commercialization after over half a century of intensive research, first on hemoglobin-based oxygen carriers and subsequently also on PFC-based products, attests that the challenges were more formidable than anticipated. This chapter will consider only the PFC approach. Since this approach has recently been reviewed extensively by the authors [8,20-22], it will be limited to a brief overview of the challenges, solutions, present state of clinical evaluation, and most recent developments. [Pg.453]

N. M. Tsoukias, D. Goldman, A. Vadapalli, R. N. Pittman, and A. S. Popel. A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. J. Theor. Biol., 2007. [Pg.305]

Blood Substitutes Hemoglobin-Based Oxygen Carriers... [Pg.353]

Given the hurdles and the costs associated with the development of a clinical product that is a new biologic, it is remarkable that at least five companies continue to be engaged in clinical trials of hemoglobin-based oxygen carriers (Table 2). Most of the companies are developing modified hemoglobins derived from natural sources (human or bovine red... [Pg.372]

Linberg, R. Conover, C.D. Shum, K.L. Shorr, R.G. Hemoglobin based oxygen carriers how much methemo-globin is too much Art. Cells Blood Subs. Immob. Biotech. 1998, 26, 133-148. [Pg.373]

Wahr, J.A. Anderson, M.M. Giacherio, D.A. Hallock, L. Gawryl, M.S. Lansden, C. Tremper, K.K. The effects of a blood-salvaging device on blood containing a hemoglobin-based oxygen carrier, HBOC-201. J. Cardiothorac. Vase. Anesthes. 1997, 11 (1), 10-12. [Pg.374]

Hughes, G.P. Yancey, E.P. Albrecht, R. Locker, P.K. Francom, S.F. Orringer, E.P. Antal, E.J. Jacobs, E.E. Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin. Pharmacol. Ther. 1995, 58, 434 43. [Pg.375]

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