Hemoglobin oxygen binding and

Many proteins bind small molecules but do not catalyze a reaction of the ligand. Some examples include the binding of oxygen by myoglobin or hemoglobin and the binding of hormones and drugs by specific receptor... 

Four possible functions of Cp have been proposed in one form or another. These are not necessarily mutually exclusive, since there is no reason why a single prominent protein may not have several important functions—e.g., hemoglobin s oxygen-binding properties and its participation in the pH-homeostatic mechanism of the blood. 

In the presence of H" and CO, both of which bind to hemoglobin, the oxygen-binding capacity of hemoglobin decreases. 

Problem 2338. If both hemoglobin and myoglobin bind oxygen reversibly, why are their binding curves qualitatively different ... 

Yonetani T, Tsuneshige A, Zhou Y, Chen X. 1998. Electron paramagnetic resonance and oxygen binding studies of alpha-nitrosyl hemoglobin a novel oxygen carrier having NO-assisted allosteric functions. JBiol Chem 273(32) 20323-20333. 

Similarly, Dean and Schechter (1979) reported that the presence of specific antibodies in stoiechiometric amount increases the affinity of hemoglobin Aq for oxygen and they concluded that antibody and oxygen binding are linked functions. 

---