Oxygen carriers, hemoglobin

These superoxo complexes are relevant models for the naturally occurring oxygen carriers hemoglobin and myoglobin, which contain ferroprotoporphyrin IX as an active center in which the sixth axial postion is occupied by the imidazole moiety of histidine.17 They also intervene as primary oxygen adducts in enzymatic cytochrome P-450 oxygenases.18... 

Aside from its welhkno vn function as an oxygen carrier, hemoglobin plays an important role as a blood buffer. In order to understand the interrelationship between oxygen uptake and release, and the buffering action of hemoglobin, we must consider the interaction of several simultaneous equilibria, A greatly simplified version of the equilibria is developed below. 

Iron. Iron is ubiquitous in biological systems. It occurs in the hemopro-teins, including the oxygen carriers hemoglobin and myoglobin in a variety of electron carriers, including the cytochromes and cytochrome oxidase and in various enzymes that catalyze distinctly different reactions. In the Fe(III) oxidation state the metal can occur in a low-spin, S = i state or a high-spin, 5 = i state. There are a few examples of an intermediate or 5 = f state. 

Fig. 1 Active site deoxy and oxy forms of the biological oxygen carriers hemoglobin (Hb), hemocyanin (He), and hemerythrin (Hr).

Artificial Oxygen Carriers (Hemoglobin-Vesicles) as a Transfusion Alternative and for Oxygen Therapeutics... 

Tsuchida E, Sou K, Nakagawa A et al (2009) Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry. Bioconjug Chem 20 1419-1440. 

MIcromlnerals (trace elements) Iron (Fe) 3600 mg Component of oxygen carrier hemoglobin... 

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