Oxygen carriers, hemoglobin synthetic

In this report we would like to discuss our results on the picosecond photodissociation experiments of the CO and O2 forms of a number of synthetic reversible oxygen carriers (1,2) and compared them to earlier picosecond absorption work on the same derivatives of the natural forms of hemoglobin. The latter work has provided us with a better understanding of the details of the photodissociation in terms of the sequential evolution of four photointermediates which were experimentally isolated, characterized, and kinetically analyzed (3,4). 

Oxygen carriers can be divided into two classes hemoglobin-based oxygen carriers, prepared from hemoglobin of human or bovine origin, and synthetic perfluorocarbons. 

The first demonstration of facilitated transport of oxygen was performed by Scholander [22] using thin films of cellulose acetate impregnated with aqueous hemoglobin solutions. Later Bassett and Schultz [65] demonstrated the process with cobalt dihistidine, a synthetic carrier. The enhancements obtained in these... 

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