Oxidative stress-related diseases

Betalains have shown strong antioxidant activities in biological environments such as membranes and LDLs," -" suggesting that the consumption of betalain-colored foods may exert protective effects against certain oxidative stress-related diseases (i.e., cancers) in humans. Beetroot has been used as a treatment for cancer in Europe for several centuries. The high content of betanin in red beetroot (300 to 600 mg/kg) may be the explanation for the purported cancer chemopreventive effects of beets. 

P5 Studies have shown that ebselen is an antiinflammatory and antioxidative agent. Its protective effect has been investigated in oxidative stress related diseases such as cerebral ischemia in recent years. However, experimental evidence also shows that ebselen causes cell death in several different cell types. Whether ebselen will have a beneficial or detrimental effect on cells under ischemic condition is not known. Herein, we studied the effect of ebselen... 

In recent years, many physiological properties of melatonin have been described resulting in much attention in the development of synthetic compounds possessing indole ring [94]. These compounds have structural similarity to melatonin. However, the therapy of oxidative stress-related diseases has not found satisfactory application in clinical practice. This may be due to the insufficient efficacy of drugs available, their unsuitable pharmacokinetics, side effects, and toxicity. 

An area of considerable interest is the antioxidant function of ascorbic acid. Ascorbic acid is probably the most effective and least toxic antioxidant present in the human body. Therefore, ascorbic acid may be important in protecting against oxidative stress-related diseases, including cancer, coronary heart disease, cataract formation, and aging. Chapters are devoted to these and other associations of ascorbic acid with disease. A related chapter is devoted to the radiation protective effect of ascorbic acid. One chapter is devoted entirely to the role of ascorbic acid in aging, while another chapter reviews the extensive epidemiological evidence for the relationship between ascorbic acid and chronic health risk. 

M. Czesnikiewicz-Guzik, S.J. Kontmek, B. Foster, G. Wisniewska, S. Majewski, Melatonin and its role in oxidative stress related diseases of oral cavity, /. Physiol. Pharmacol, 58 (Suppl 3), 5-19, 2007. 

Com oil phenols have been studied with respect to their potential to scavenge the free radicals, the peroxyl radicals, the superoxide radicals, etc. The free radical scavenging activity of the phenolic acids using model free radicals such as l,7-diphenyl-2-picrylhydrazyl radical (DPPH ), or ABTS (2,2 -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt cation radical) is often measured. TEAC (Trolox equivalent antioxidant capacity), FRAP (Ferric-reducing antioxidant capacity) and TRAP (total-radical-trapping antioxidant parameter) of the com oil are also used in order to obtain additional information, necessary to investigate the relation between the antioxidant intake and the oxidative stress related diseases (Stratil et al., 2008 Ceto et al., 2014 Apak et al., 2007). 

Bacellar H, Munoz A et al (1994) Temporal trends in the incidence of HIV-l-related neurologic diseases Multicenter AIDS Cohort Study, 1985-1992. Neurology 44(10) 1892-1900 Banki K, Hutter E et al (1998) Molecular ordering in HIV-induced apoptosis. Oxidative stress, activation of caspases, and cell survival are regulated by transaldolase. . J Biol Chem 273(19) 11944-11953... 

Phagocyte-derived ROMs have been implicated in the pathogenesis of a number of pulmonary diseases, including emphysema, acute respiratory distress syndrome, and various environmental diseases such as asbestos-related fibrosis and cancer (Mossman and Marsh, 1985). The relatively high oxygen tension in pulmonary tissue renders the lung prone to oxidative stress (Edwards and Lloyd, 1988). 

---