Stress-related diseases

Betalains have shown strong antioxidant activities in biological environments such as membranes and LDLs," -" suggesting that the consumption of betalain-colored foods may exert protective effects against certain oxidative stress-related diseases (i.e., cancers) in humans. Beetroot has been used as a treatment for cancer in Europe for several centuries. The high content of betanin in red beetroot (300 to 600 mg/kg) may be the explanation for the purported cancer chemopreventive effects of beets. 

Sapolsky, R. M. (1998), Why Zebras don t get Ulcers A Guide to Stress, Stress-Related Disease, and Coping, 2nd Edn, W. H. Freeman, New York. 

With this background there is an obvious call for novel strategies to follow changes of complex molecular patterns of different stress-related diseases over days, weeks, months, and years as an effect of lifestyle and the psychosocial environment to reflect the effects of unhealthy environments. The molecular interactions between the brain and the immune system in health and disease are reflected in the circulatory system as the white blood cells, the lymphocytes, mimic ongoing activities in the brain. By using lymphocytes from patients with psychosomatic-psychiatric diseases we can find detailed information about protein-peptide translational modifications and transformation essential for the development of new approaches that can prevent and treat major psychiatric diseases. 

P5 Studies have shown that ebselen is an antiinflammatory and antioxidative agent. Its protective effect has been investigated in oxidative stress related diseases such as cerebral ischemia in recent years. However, experimental evidence also shows that ebselen causes cell death in several different cell types. Whether ebselen will have a beneficial or detrimental effect on cells under ischemic condition is not known. Herein, we studied the effect of ebselen... 

In recent years, many physiological properties of melatonin have been described resulting in much attention in the development of synthetic compounds possessing indole ring [94]. These compounds have structural similarity to melatonin. However, the therapy of oxidative stress-related diseases has not found satisfactory application in clinical practice. This may be due to the insufficient efficacy of drugs available, their unsuitable pharmacokinetics, side effects, and toxicity. 

An area of considerable interest is the antioxidant function of ascorbic acid. Ascorbic acid is probably the most effective and least toxic antioxidant present in the human body. Therefore, ascorbic acid may be important in protecting against oxidative stress-related diseases, including cancer, coronary heart disease, cataract formation, and aging. Chapters are devoted to these and other associations of ascorbic acid with disease. A related chapter is devoted to the radiation protective effect of ascorbic acid. One chapter is devoted entirely to the role of ascorbic acid in aging, while another chapter reviews the extensive epidemiological evidence for the relationship between ascorbic acid and chronic health risk. 

M. Czesnikiewicz-Guzik, S.J. Kontmek, B. Foster, G. Wisniewska, S. Majewski, Melatonin and its role in oxidative stress related diseases of oral cavity, /. Physiol. Pharmacol, 58 (Suppl 3), 5-19, 2007. 

Many occupational diseases are associated with specific occupations, e.g. silicosis with the pottery industry, byssinosis with the cotton industry. Whilst improvements in working conditions have greatly reduced the incidence of such diseases, routine monitoring of workers not exposed to these conditions is an important feature of occupational health practice. Here the principal objective is that of controlling diseases and conditions prevalent in industrial populations with a view to their eventual eradication. This form of monitoring also makes a great contribution to the control of stress-related diseases and conditions, such as mental illness and heart disease. 

Com oil phenols have been studied with respect to their potential to scavenge the free radicals, the peroxyl radicals, the superoxide radicals, etc. The free radical scavenging activity of the phenolic acids using model free radicals such as l,7-diphenyl-2-picrylhydrazyl radical (DPPH ), or ABTS (2,2 -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt cation radical) is often measured. TEAC (Trolox equivalent antioxidant capacity), FRAP (Ferric-reducing antioxidant capacity) and TRAP (total-radical-trapping antioxidant parameter) of the com oil are also used in order to obtain additional information, necessary to investigate the relation between the antioxidant intake and the oxidative stress related diseases (Stratil et al., 2008 Ceto et al., 2014 Apak et al., 2007). 

SHANKS, N. LiGHTMAN, s. L. (2001) The matemal-neonatal neuro-immune interface are there long-term implications for inflammatory or stress-related disease Journal of Clinical Investigation. 108,1567-1574. 

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