Ovule increase

PCB diets were associated with reproductive impairment including anovulation, fetal resorption, delayed ovulation, increased gestation, and decreased litter size. Hepatic estrogen binding site concentrations decreased with increasing dietary PCB concentrations but not uterine estrogen receptor sites... 

Reproductive System. The primary PGs are intimately involved in reproductive physiology (67). PGE2 and PGP2Q, are potent contractors of the pregnant utems and intravenous infusion of either of these compounds to pregnant humans produces a dose-dependent increase in frequency and force of uterine contraction. PGI2 and TXA2 have mild relaxant and stimulatory effects, respectively, on uterine tissue. The primary PGs also play a role in parturition, ovulation, luteolysis, and lactation and have been impHcated in male infertility. 

In breast cancer patients, total PR status is measured for hormonal treatment. The presence of PR is associated with increased survival rates and hormonal responsiveness of mammary tumors. PR agonists are widely used in contraception, HRT, breast cancer, and endometrial hyperplasia. Antiprogestins such as RU486 are used for blocking ovulation and preventing implantation, and in addition they are in clinical testing for the induction of labor and to control various neoplastic transformations. 

Clomiphene (Clomid) is a synthetic nonsteroidal compound that binds to estrogen receptors, decreasing the amount of available estrogen receptors and causing the anterior pituitary to increase secretion of FSH and LH. It is used to induce ovulation in anovulatory (nonovulating) women. 

The effects of raloxifene in premenopausal women have been analyzed in subjects with normal ovarian function treated with high doses (100 to 400 mg daily) at either different time points of their menstrual cycle or continuously for 4 weeks (Baker et al. 1998). Raloxifene did not prevent ovulation, nor did it alter the length of the menstrual cycle or the day of the LH surge. However, it did stimulate FSH secretion, increase serum estradiol levels, and decrease serum PRL. These results are also similar to those reported for premenopausal women taking tamoxifen (Jordan et al. 1991) and are indicative of some antiestrogenic action at either the hypothalamic and/or pituitary level. 

Intermediate-duration studies with treated females show that exposure to chlordecone may result in persistent vaginal estrus, decreased ovulation, and reproductive failure. Persistent vaginal estrus was observed in female mice at doses as low as 2 mg/kg/day for 3-6 weeks (Huber 1965 Swartz and Mall 1989 Swartz et al. 1988). Increased atresia of follicles (Swartz and Mall 1989), decreased ovulation (Swartz et al. 1988), and small and medium-sized follicles (Swartz and Mall 1989) have been observed after 4 weeks of exposure to 8 mg/kg/day of chlordecone. Similarly, decreased corpora lutea have been observed following administration of 3.9 mg/kg/day for 130 days (Huber 1965). Decreased numbers of litters or complete reproductive failure have been observed after exposure of female rats to 1.62-1.71 mg/kg/day for 4.5 months or female mice to 5.2 mg/kg/day for 160 days (Huber 1965). 

They must remain mobile for a considerable period of time, many hours, in the uterus and oviduct to increase the chance of meeting an ovum after ovulation. Spermatozoa can survive in the female genital tract 30 to 50 hours. 

Antibiotic revolution has provided long and healthy life to people. The life expectancy has almost doubled. The increased population has caused many social problems in terms of food resources, environmental issues, employment, etc. To control these problems, population is required to be controlled. This has lead to the concept of family planning. Antifertility drugs are of use in this direction. Birth control pills essentially contain a mixture of S)mthetic estrogen and progesterone derivatives. Both of these compounds are hormones. It is known that progesterone suppresses ovulation. Synthetic progesterone derivatives are more potent than... 

Traditionally, French fishermen have used the male sex attractant of the sea lamprey, Petromyzon marinus. They bait a trap with an adult male and catch numerous females at night. Land-locked sea lamprey such as those in the Great Lakes of North America spawn in streams. Males arrive before the females and build nests. In laboratory choice experiments, ovulating females selected water from spermiating males and increased their searching behavior there. In a natural stream, females responded to male odors from as far as 65 m. The active... 

Under certain conditions, ovulation and plasma gonadotropin levels can be stimulated by ovarian fluid from other ovulated females. The African catfish, Clariasgaricpinus, is an example. It lives in muddy water and spawns at night, conditions expected to favor pheromone commimication. Moreover, this species is a seasonal breeder, spawning after rainfall. The sudden mass spawning requires synchronization. Water from males or ovulated females, and also ovarian fluid of ovulated females, experimentally induced ovulation in 67% of females. Plasma gonadotropin was also increased by these treatments (Resink etal., 1989c). 

The prairie vole, M. ochrogaster, is an induced ovulator. Adult male urine, placed on the nose of females, stimulates weight increase of the uterus. The vomeronasal organ plays a role in this effect (Carter etah, 1980). 

An extract of secretion from the sebaceous glands on head and neck of sexually active feral billygoats increases the number of does ovulating. The extract was placed on cotton wool and worn in facemasks. 4-Ethyloctanoic acid and 4-methyloctanoic acid, responsible for the goaty odor, were not active but both the free fatty acid and lipid-free non-acid fractions were. The 4-ethyl branched fatty acids are present in the active fraction (Birch etal., 1989). 

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