Progesterone derivatives

Chemical Analysis. Chemically, the various progestogens belong to one of three classes. Estranes are 19-nortestosterone derivatives (Fig. 1) gonanes are 19-nortestosterone derivatives with a C-13 ethyl group (Fig. 2) and pregnanes are 17-alpha-OH progesterone derivatives similar in stmcture to progesterone itself. 

These observations, while implicating steroids in brain function and behaviour, cannot be taken as a reliable indicator of their actual effect on neuronal function. Nevertheless, some neurosteroids produce CNS depression with a rapid inhibition of neuronal excitability and one progesterone derivative, alphaxalone (3a-hydroxy-5a pregnane-11, 20 dione, see Fig. 13.5) has been used effectively as an intravenous anaesthetic in humans. 

Information does not concern either the sex or the stage of development bIncludes progesterone derivates pregnanediones, pregnenolones and pregnanediols... 

Antibiotic revolution has provided long and healthy life to people. The life expectancy has almost doubled. The increased population has caused many social problems in terms of food resources, environmental issues, employment, etc. To control these problems, population is required to be controlled. This has lead to the concept of family planning. Antifertility drugs are of use in this direction. Birth control pills essentially contain a mixture of S)mthetic estrogen and progesterone derivatives. Both of these compounds are hormones. It is known that progesterone suppresses ovulation. Synthetic progesterone derivatives are more potent than... 

Progesterone derives from the ovary (mainly from the corpus luteum) and from the placenta and is involved in uterine endometrium differentiation for embryo implantation,... 

It is thought that progesterone derivatives have the least effect on liver metabolism and provide a reliable assurance against pregnancy. Hepatic disturbance is not considered a contraindication to progesterone therapy [2], but in practice the method cannot be recommended in active viral hepatitis or severe decompensated cirrhosis [4], Viral hepatitis carriers can use the POC methods in any circumstance [30]. When patients with acute hepatitis recover fully and LFTs have returned to normal, the full spectrum of contraceptive choices can be considered however, such patients should be monitored carefully during the initiation period [2]. 

Charlet A, Lasbennes F, Darbon P, Poisbeau P (2009) Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. Pain 139(3) 603-609... 

The acylation of organocadmium reagents with acid chlorides such as (115) formed an early method for synthesis of progesterone derivatives such as 21-methyl progesterone (equation 97). The same transformation may be accomplished more easily with palladium-catalyzed organotin acylation in 45%... 

Rather little attention is normally paid to the intensities of i.r. absorption bands of steroids, but two papers now detail interesting variations in v(C=0) for primary, secondary, and tertiary acetoxy-groups,85 and in v(C=0) and v(C=C) for variously substituted progesterone derivatives.85-86 I.r. absorption intensities of progesterone derivatives have been studied with a Fourier-transform spectrometer.87... 

Scheme 7.29 Synthesis of a progesterone-derived amide via a solid-supported active ester formation using N-hydroxysuccinimide resin 89.

Viger, A., S. Coustal, S. Perard, A. Piffeteau, and A. Marquet (1989). 18-Substituted progesterone derivatives as inhibitors of aldosterone biosynthesis. J. Steroid Biochem. 33, 119-124. 

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