Orphans

Kerridge has provided an excellent article on the interface betw een the operating company and the contractor to define all requirements in complete and standardized detail. This includes who is responsible for every deliverable. The operating company and contractor must work as a team. An example of one area that needs to be reviewed often with the contractor is the provision of secondary systems as packages, perhaps from a third party. Such systems can easily become orphans. This problem is discussed in the Process Definition section of Chapter 16. 

Orphan receptor, a gene product that is predicted to be a receptor through structure and spontaneous interaction with G-proteins but for which there is no known endogenous ligand or physiological function. 

Q-test for rejection of, 252t weighting, 237-239 Degrees of freedom, 241 De-orphanization, 180 Dependent variables, 35, 162 Depolarization thresholds, 16 Descriptive statistics... 

One-way analysis of variance, 229-230, 230f—231f Operational model derivation of, 54-55 description of, 45—47, 46f function for variable slope, 55 for inverse agonists, 221 of agonism, 47f orthosteric antagonism, 222 partial agonists with, 124, 220-221 Opium, 147 Orphan receptors, 180 Orthosteric antagonism... 

Tang Herbal, 147 Target-based drug discovery biological targets, 180-184 chemical end point in, 180 chemical tools, 178-179 definition of, 5 description of, 175-177 linear approach, 176 orphan receptors, 180 preclinical process in, 176-177 random variation in gene expression, 178... 

High-throughput Screening Combinatorial Chemistry Orphan Receptors... 

Bosentan (Tracleer ) Actelion, Switzerland ETA/ETB receptor Grade III and IV PAH and chronic thromboembolic pulmonary hypertension (European approval in 2002 as orphan medicine) Program for CHF was terminated in phase III... 

TBC11251 (Sitaxsentan) Texas Biotechnology, USA ETA receptor Grade III PAH (designated orphan medicine in 2004)... 

Kodama S, Negishi M (2006) Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR. Drug Metab Rev 38 75-87... 

---