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Orphan Opioid Receptors

Pomonis, J.D., Billington, C.J., Levine, A.S. Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats, NeuroReport 1996, 8, 369-371. [Pg.475]

Halford WP, Gebhardt BM, CaiT DJ (1995) Functional role and sequence analysis of a lymphocyte orphan opioid receptor. J Neu-roimmunol 59 91-101. [Pg.492]

Henderson. G. et al. (1997) The orphan opioid receptor and its endogenous ligarKl - nociceptin/orphanin FQ. Trends Pharmacol. ScL. 18.293-300. Alexander. S.P.H. er al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Sci.. Su/. . IS, 1-98. [Pg.209]

In subsequent studies, two research groups found a heptadecapeptide (Phe-Gly-Gly-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Lys-Ala-Asn-GIn) to be the endogenous peptide for the orphan opioid receptor. [Pg.976]

Henderson G, McKnight AT. The orphan opioid receptor and its endogenous ligand —nociceptin/orphanin FQ. Trends Pharmacol Sci 1997 18 293-300. [Pg.1014]

ORLl receptor, acronym of orphan opioid receptor-like receptor ( nodceptin). [Pg.253]

A 17 amino acid long peptide sequentially related to opioid peptides in particular dynorphin A. OFQ/N is inactive at the 5, k, and p opioid receptors, but binds to its own NOP receptor (formerly ORL-1, for opioid receptor like-1). In contrast to opioid peptides, OFQ/N has no direct analgesic properties. OFQ/N is the first example for the discovery of a novel neurotransmitter from tissue extracts by using an orphan receptor as bait. Centrally administered in rodents, OFQ/N exerts anxiolytic properties. OFQ/N agonists and antagonists... [Pg.917]

The cloning of the delta receptor set in motion a competitive race to identify other members of the opioid receptor family. Homologous orphan clones were quickly assessed for opioid receptor binding properties, which resulted in the identification of the kappa receptor and reassignment of an orphan clone as the delta opioid receptor [31]. PCR, genomic, and cDNA screens revealed the mu opioid receptor and an extremely abundant orphan member, named opioid receptor-like (ORL-1) receptor (reviewed by Massotte and Kieffer [30]). [Pg.21]

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See also in sourсe #XX -- [ Pg.307 ]



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Opioid receptors

Opioids receptors

Orphan

Orphan receptors

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