Retinoid-related orphan receptor

Steinmayr, M., Andre, E., Conquet, F., Rondi-Reig, L., Delhaye-Bouchaud, N., Auclair, N., Daniel, H., Crepel, F., Mariani, J., Sotelo, C. and Becker-Andre, M., 1998, staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice, Proc Natl Acad Sci USA, 95, pp 3960-5. 

EMERGING ROLE OF RETINOID-RELATED ORPHAN RECEPTOR (ROR) AND ITS CROSS TALK WITH LXR (LIVER X RECEPTOR) IN THE REGULATION OF DRUG-METABOLIZING ENZYMES... 

Carlberg, C., Hooft van Huijsduijnen, R., Staple, J. K., DeLamarter, J. F., and Becker-Andre, M. (1994) RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol. Endocrinol. 8, 757-770. 

Jetten, A. M. and Joo, J. H. (2006) Retinoid-related orphan receptors (RORs) roles in cellular differentiation and development. Adv. Dev. Biol. 16, 314-354. 

Srinivas, M., Ng, L., Liu, H., Jia, L., and Forrest, D. (2006) Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta. Mol. Endocrinol. 20, 1728-1741. 

Kurebayashi, S., Ueda, E., Sakaue, M., Dhavalkumar, D., Patel, D. D., Medvedev, A., Zhang, F., and Jetten, A. M. (2000) Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl Acad. Sci. USA 97, 10132-10137. 

Kurebayashi, S., Nakajima, T., Kim, S. C., Chang, C. Y., McDonnell, D. P, Renaud, J. P., and Jetten, A. M. (2004) Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem. Biophys. Res. Commun. 315, 919-927. 

Logue, M.W., Baldwin, C., Guffanti, G., et al., 2013. A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol. Psychiatry 18, 937-942. 

FLORES MV, HALL c, JURY A, CROSIER K, CROSIER p (2007), The zebrafish retinoid- related orphan receptor (ror) gene family . Gene Expression Patterns, 7, 535-43. 

The ligand binding pocket of USP is filled by a fortuitous phospholipid co-purified and co-crystallized with the USP LBD that was fiirther characterized by mass-spectroscopic and chemical analysis [57]. In a similar way, recent crystallographic investigations of the retinoid-acid related orphan receptor (3 (ROR (3) [58] and of the heterodimeric complex RARa/RXRa [30] revealed an E.coli endogeneous fatty acid in the ROR (3 and in the RXRa subunit, respectively. 

Missbach, M., Jagher, B., Sigg, I., Nayeri, S., Carlberg, C., and Wiesenberg, I. (1998) Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor/retinoid acid receptor-related orphan receptor a with potent antiarthritic activity. J. Biol. Chem. 271, 13515-13522. 

Melatonin is an indole-derived anterior pituitary hormone that causes downstream inhibition of a-MSH-induced melanogenesis. Melatonin is antiamnesic, synchronizes circadian and circannual rhythms and is metabolized to 5-methoxytryptamine. Melatonin acts via GPCRs MT1 and MT2 (which both couple through Gai and cAMP decrease). MT1 may also couple via Gao and Gaq to activate PLC (and hence increase cytosolic Ca2+) and via G Gy activation of PLA2. Melatonin can further interact with nuclear receptor superfamily orphan retinoid receptors RZR/ROR. Melatonin fluctuates with a circadian rhythm and is elevated in blood during the night. Melatonin is accordingly of social importance in relation to shift work and jet-lag. Melatonin and 5-methoxytryptamine occur in some plants (Table 5.8). 

Harris, J.M., Lau, P., Chen, S.L. and Muscat, G.E. (2002) Characterization of the retinoid orphan-related receptor-a coactivator binding interface a structural basis for ligand-independent transcription. Molecular Endocrinology, 16, 998-1012. 

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