Organotin toxicity

Triebskom, R., R.D. Negele, J. Schwaiger, H. Rahmann, and T. Braunbeck. 1994c. Myehn in the central nervous system of rainbow trout (Oncorhynchus mykiss) as a target for organotin toxicity. Verhand. 

Mushak P, Krigman MR, Mailman RB. 1982. Comparative organotin toxicity in the developing rat Somatic and morphological changes and relationship to accumulation of total tin. Neurobehav Toxicol Teratol 4 209-215. 

The advantages claimed for organotin polymer-based antifouling paints include constant toxicant deHvery vs time, erosion rate and toxicant deHvery are controUable, no depleted paint residue to remove and dispose, 100% utilization of toxicant, polishing at high erosion rates, surface is self-cleaning, and function is continuously reactivated. 

ORGANOTIN PESTICIDES, FLAMMABLE LIQUID, TOXIC, n.o.s., flash 2787 ... 

Toxic Reactions of the Skin Irritation is the most common reaction of the skin. Skin irritation is usually a local inflammatory reaction. The most common skin irritants are solvents dehydrating, oxidizing, or reducing compounds and cosmetic compounds. Acids and alkalies are common irritants. Irritation reactions can be divided into acute irritation and corrosion. Necrosis of the surface of the skin is typical for corrosion. Acids and alkalies also cause chemical burns. Phenols, organotin compounds, hydrogen fluoride, and yellow phosphorus may cause serious burns. Phenol also causes local anesthesia, in fact it has been used as a local anesthetic in minor ear operations such as puncture of the tympanous membrane in cases of otitis. ... 

Although toxic agents have the potential to cause necrosis, some of them can interfere with intracellular signaling pathways and induce apoptosis instead of necrosis. It seems that organotin(IV) compounds exert their toxic effects involving all these processes. The precise balance of these actions and their outcomes may differ radically from one cell type to another and among different organisms. 

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