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Orexin regulation

Mood and hedonic value associated with feeding, food intake, foraging, consummatory behaviors, and craving in addiction complex regulation by food entrainable oscillators in the brain and periphery, neuropeptides (including orexins) and biogenic amines. [Pg.208]

Lesions of the lateral hypothalamic area (LHA) cause anorexia, whereas ablation of the paraventricular nucleus (PVN) cause a hyperphagic obesity syndrome. Consistent with these results, LHA neurons express the orexigenic neuropeptides MCH and orexin. PVN neurons produce several neuropeptides that are anorex-igenic when administered directly into the brain (CRH, TRH, oxytocin), in addition to their better known roles as endocrine regulators. LHA and PVN receive rich inputs from axons of NPY/AgRP and aMSH/CART-producing neurons in the arcuate nucleus. [Pg.211]

Chemelli, R. M., Willie, J. T., Sinton, C. M. et al. (1999). Narcolepsy in orexin knockout mice molecular genetics of sleep regulation. Cell 98, 437-51. [Pg.48]

Sakurai, T., Amemiya, A, Ishii, M. el al. (1998). Orexins and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-85. [Pg.55]

Bayer, L., Mairet-Coello, G., Risold, P. Y. 8r Griffond, B. (2002). Orexin/hypocretin neurons chemical phenotype and possible interactions with melanin-concentrating hormone neurons. Regul. Pept. 104, 33-9. [Pg.99]

Guan, J. L., Uehara, K., Lu, S. et at (2002). Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus a novel circuit implicated in feeding regulation. Int. J. Obes. Relat. Metab. Disord. 26, 1523-32. [Pg.102]

Yamanaka A., Muraki Y., Ichiki K el al. (2006). Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. J. Neurophysiol. Epub-ahead of print. [Pg.223]

Figure 13.2 Schematic representation of the molecular mechanisms of sleep wake regulation by PGD2, PGE2, adenosine, histamine, and orexin. Figure 13.2 Schematic representation of the molecular mechanisms of sleep wake regulation by PGD2, PGE2, adenosine, histamine, and orexin.
The second constellation of narcoleptic symptoms can be summarized under the rubric of excessive daytime sleepiness, or an inability to regulate wakefulness. As recently reviewed by Mochizuki et al. (2004), at least four explanations have to date been proposed for this sleepiness a deficit in arousal, an impaired circadian alertness signal, abnormal homeostatic regulation of non-REM sleep, and excessive vigilance state fragmentation. These mechanisms are not mutually exclusive, and there are possible roles for orexin signaling in each of them, as we review in the following sections. [Pg.419]

Orexin deficiency and abnormal regulation of non-REM sleep homeostasis... [Pg.422]

Yamanaka, A., Beuckmann, C. T., Willie, J. T. et al. (2003). Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701-13. [Pg.432]

Sakurai T. (2005). Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis. Sleep Med. Rev. 9, 231-41. [Pg.458]

Yamanaka A., Muraki Y Tsujino N., Goto K., Sakurai T. (2003). Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem. Biophys. Res. Commun. 303, 120-9. [Pg.461]

Control of feeding behavior involves peripheral peptides (insulin, ghrelin, leptin) plus several peptides in the CNS (orexins/hypocretins, CCK, galanin, MSH, neuropeptide Y, CRH, cocaine-and-amphetamine-regulated transcript (CART)) [35, 36]. Some of the same peptides are involved in reward systems crucial to drug addiction. Specific receptor blockers are being tested for many of these peptide-receptor systems, with the hope of very selective actins with minimal side effects [35], For example, there are two CCK receptor subtypes, CCK-A and... [Pg.330]


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See also in sourсe #XX -- [ Pg.68 , Pg.318 , Pg.322 , Pg.323 ]




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