Melanin-concentrating hormone

The lateral hypothalamic area has been identified as a feeding centre by studies involving electric stimulation and discrete lesions. Neurons in the lateral hypothalamic area and the neighbouring perifornical area express neuropeptides that stimulate feeding when injected into cerebral ventricles (orexins 1 and 2, melanin-concentrating hormone (MCH)). 

Melanin-concentrating hormone (MCH) is a cyclic neuropeptide of 19 amino acids. It is involved in the modulation of feeding behavior. Its actions are mediated by G-protein coupled receptors (MCH1 and MCH2). 

MDR-ABC Transporters Mechanism-based Inhibition Meglitinide-related Compounds Melanin-concentrating Hormone Melanocortins... 

Guyon A, Banisadr G, Rovere C, Cervantes A, Kitabgi P, MeUk-Parsadaniantz S, Nahon JL (2005b) Complex effects of stromal cell-derived factor-1 alpha on melanin-concentrating hormone neuron excitabUity. Eur J Neurosci 21 701-710... 

Figure 1.6 (A) Changes in c-Fos IR in hypocretin/orexin(HCRT+)- containing neurons in response to BIC treatment as a function of distance from the microdialysis probe. The percentage of double-labeled cells was greatest closer to the probe (grids 1 and 2, compared with 3 and 4) and was greater with higher concentrations or exposure times. Contralateral cells were not affected. (B) Much lower percentages of melanin-concentrating hormone (MCH+) exhibited c-Fos IR activation in response to BIC. From Alam et al. (2005).

Alam, M. N., Kumar, S., Bashir, T. et al. (2005). GABA-mediated control of hypocretin-but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats. ]. Physiol. 563, 569-82. 

Bayer, L., Mairet-Coello, G., Risold, P. Y. 8r Griffond, B. (2002). Orexin/hypocretin neurons chemical phenotype and possible interactions with melanin-concentrating hormone neurons. Regul. Pept. 104, 33-9. 

Gao, X. B. van den Pol, A. N. (2001). Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus./. Physiol. 533, 237-52. 

Goutagny, R., Luppi, P. FL, Salvert, D Gervasoni, D. Fort, P. (2005c). GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle. Neuroreport 16, 1069-73. 

Guan, J. L., Uehara, K., Lu, S. et at (2002). Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus a novel circuit implicated in feeding regulation. Int. J. Obes. Relat. Metab. Disord. 26, 1523-32. 

Bayer, L., Eggermann, E., Serafin, M. et al. (2005). Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices. Neuroscience 130, 807-11. 

Saito, Y., Cheng, M., Leslie, F. M. Civelh, O. (2001). Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J. Comp. Neurol 435, 26-40. 

Shimada, M., Tritos, N. A, Lowell, B. B., Flier, J. S. 8r Maratos-Flier, E. (1998). Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-4. 

Comparison of hypocretm/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain. J. Chem. Neuroanat. 27, 165-81. 

Diaryl-octahydro-pyra/ino[2,1 -c 1,4]thiazines are useful as melanine concentrating hormone receptor ligands <2002W02002/094799>. Pyrazino[2,l-f][l,4]oxazines 245 (Y = 0) and pyrazino[2,1 -c][ 1,4]thiazines 245 (Y = S) exert a tachykinin antagonistic effect <2002W0055518>. 

Kokkotou, E. G., Tiitos, N. A., Mastaitis, J. W., Slieker, L., and Maratos-Flier, E. (2001) Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. 142, 680-686. 

Segal-Lieberman, G., Bradley, R. L., Kokkotou, E., et al. (2003) Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc. Natl. Acad. Sci. U. S. A. 100, 10085-10090. 

Melanin concentrating hormone Amgen, Inc. [11] receptor antagonist... 

Melanin-concentrating hormone, an orexigenic hypothalamic neuropeptide, has recently been shown to be likely to induce anxiogenic effects (Borowski et al. 2002 but see Monzon and deBarioglio 1999). 

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