Hypothalamic neuropeptide

Central nervous system Reduction of body weight Reduced appetite changed expression of anorexigenic (e.g., POMC) and orexigenic (e.g., NPY) hypothalamic neuropeptides... 

Hypocretin A wakefulness-promoting hypothalamic neuropeptide, a deficiency of which is involved in the pathophysiology of narcolepsy. 

Sakurai, T., Amemiya, A, Ishii, M. el al. (1998). Orexins and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-85. 

Melanin-concentrating hormone, an orexigenic hypothalamic neuropeptide, has recently been shown to be likely to induce anxiogenic effects (Borowski et al. 2002 but see Monzon and deBarioglio 1999). 

Inui, A. (1999) Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin. Trends Neurosci. 22, 62-67. 

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexin and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573-585. 

Pan H, Che FY, Peng B, Steiner DF, Pintar JE, Fricker LD. The role or prohormone convertase-2 in hypothalamic neuropeptide processing a quantitative neuropeptidomic study. J. Neurochem. 2006 98 1763-1777. 

Gloyer, i., Wilson, S., Buckingham, R., Arch, J., Tray hum, P, and Williams, G. (1997). Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Dwhftes 46, 335-341. 

Hypothalamic neuropeptide Y and agouti mRNAs Brain dopamine levels INC (12) ... 

Bai FL, Yamano M, Shiotani Y, Emson PC, Smith AD, et al. 1985. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 331 172-175. 

Billington CJ, Levine AS. 1992. Hypothalamic neuropeptide Y regulation of feeding and energy metabolism. Curr Opin Neurobiol 2 847-851. 

Hansen MJ, Jovanovska V, Morris MJ. 2004. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 88 909-916. 

Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, et al. 1999. Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140 4551-4557. 

Schwartz M W. Baskin DG, Bukowski TR, Kuijper JL, Foster D, et al. 1996. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 531-535. 

Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, et al. 1992. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130 3608-3616. 

Kalra, S.P, Sahu, A. Kalra, PS. (1990) Hypothalamic neuropeptide Y a circuit in the regulation of gonadotropin secretion and feeding behaviour. Ann. N. York Acad. Sci. 611, 273-283. 

Akabayashi, A., Watanabe, Y., Wahlestedt, C., McEwen, B.S., Paez, X. Leibowitz, S.F. (1994) Hypothalamic neuropeptide Y, its gene expression and receptor activity Relation to circulating corticosterone in adrenalectomized rats. Brain Res. 665, 201-212. 

Beck, B., Burlet, A., Nicolas, J.P. Burlet, C. (1990) Hypothalamic neuropeptide Y (NPY) in obese Zucker rats Implications in feeding and sexual behaviours. Physiol. Behan. 47, 449-453. 

Brady, L.S., Smith, M.A., Gold, P.W. Herkenham, M. (1990) Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52,441-447. 

Chua, S.C., Jr, Brown, A.W., Kim, J., Hennessey, K.L., Leibel, R.L. Hirsch, J. (1991) Food deprivation and hypothalamic neuropeptide gene expression effects of strain background and the diabetes mutation. Brain Res. Mol. Brain Res. 11, 291-299. 

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