Nuclear factor kB

Nuclear factor-KB Nuclear factor-kappa B (NF-kB) is a transcription factor that regulates cytokine production. 

Kim EJ, Hye KJ, Yong KK, et al. Suppression by a sesquiterpene lactone from Carpe-sium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-KB activation. Biochem Pharmacol 2001 61 903-910. 

Chen, Z., Gardi, J., Kushikata, T., Fang, J. Krueger, J. M. (1999). Nuclear factor kB -like activity increases in murine cerebral cortex after sleep deprivation. Am. J. Physiol. 276, R1812-18. 

NFkB, nuclear factor kB BAPP, amyloid precursor protein ... 

Simon, M. M. et al., UVB light induces a nuclear factor kB (NFkB) activity independently from chromosomal DNA damage in cell-free cytosolic extracts, J. Invest. Dermatol. 102, 422 127, 1994. 

TF transcription factor, R receptor, Fur ferric uptake regulation protein, NF-kB nuclear factor-kB, AP-1 activator protein-1, Egr-1 early growth response-1, VDR la,25-dihydroxy-vitamin D3 receptor, RXR retinoid X receptor, PPARy peroxisome proliferator-activated receptor y NFAT nuclear factor of activated T-cells, HSF heat shock factor, p53 tumor suppressor p53, HIF-1 hypoxia inducible factor-1. ... 

Pathway selective ER ligands have been reported that selectively inhibit nuclear factor kB (NF-kB) mediated gene expression [71], Since NF-kB is a pivotal regulator of pro-inflammatory gene expression, ligands that selectively inhibit the NF-kB pathway could be developed for the treatment of chronic inflammatory diseases such as arthritis, atherosclerosis, sepsis, and inflammatory bowel disease... 

Bharti, A. C., and Aggarwal, B. B. (2002). Nuclear factor-KB and cancer Its role in prevention and therapy. Biochem. Pharmacol. 64, 883-888. 

Higuchi, M., Singh, S., Chan, H., and Aggarwal, B. B., 1995, Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor -kB activation, cytotoxicity, and differentiation. Blood 86 2248-2256. 

Blanco-Colio, L.M., Valderrama, M., Alvarez-Sala, L.A., Bustos, C., Ortego, M., Hernandez-Presa, M.A., Cancelas, P., Gomez-Gerique, J., Millan, J., and Egido, J., Red wine intake prevents nuclear factor-KB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation, 102, 1020, 2000. 

Choi, J.S., Choi, Y.J., Park, S.H., Kang, J.S., and Kang, Y.H., Flavones mitigate tumor necrosis factor-a-induced adhesion molecule upregulation in cultured human endothelial cells role of nuclear factor-KB, J. Nutr., 134, 1013, 2004. 

Kumar, A., Dhawan, S., Hardegen, N.J., and Aggarwal, B.B., Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-KB activation, Biochem. Pharmacol, 55, 775, 1998. 

Kim, S.H. et al., Luteolin inhibits the nuclear factor-KB transcriptional activity in Rat-1 fibroblasts, Biochem. Pharmacol., 66, 955, 2003. 

Chung CH, Parker JS, Ely K et al. Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-Kb signaling as characteristics of a high-risk head and neck squamous cell carcinoma. CuwcerRe 2006 66 8210-8218. 

Kearns AE, Khosla S, Kostenuik PJ Receptor activator of nuclear factor kb ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008 29 155. [PMID 18057140]... 

The A3 Receptor and the Phosphatidylinositol 3-Kinase/ Protein Kinase B/Nuclear Factor-kB (PI3-K/AKT/NF-kB) Signal Transduction Cascade... 

Cooper DMF, Mons N, Karpen JW (1995) Adenylyl cyclases and the interaction between calcium and cAMP signaling. Nature 374(6521) 421—424 Cowen DS, Molinoff PB, Manning DR (1997) 5HT1A receptor mediated increases in receptor expression and activation of nuclear factor-KB in transfected Chinese hamster ovarycells. Mol Pharmacol 52(2) 221-226... 

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