Nuclear factor kB activators

Kim EJ, Hye KJ, Yong KK, et al. Suppression by a sesquiterpene lactone from Carpe-sium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-KB activation. Biochem Pharmacol 2001 61 903-910. 

Higuchi, M., Singh, S., Chan, H., and Aggarwal, B. B., 1995, Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor -kB activation, cytotoxicity, and differentiation. Blood 86 2248-2256. 

Blanco-Colio, L.M., Valderrama, M., Alvarez-Sala, L.A., Bustos, C., Ortego, M., Hernandez-Presa, M.A., Cancelas, P., Gomez-Gerique, J., Millan, J., and Egido, J., Red wine intake prevents nuclear factor-KB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation, 102, 1020, 2000. 

Kumar, A., Dhawan, S., Hardegen, N.J., and Aggarwal, B.B., Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-KB activation, Biochem. Pharmacol, 55, 775, 1998. 

Rahman, I., 2000. Regulation of nuclear factor-KB, activator protein-1, and glutathione levels by tumor necrosis factorand dexamethasone in alveolar epithelial cells. Biochem Pharmacol 60(8) 1041-1049. 

Ye J, Zhang X, Young HA, et al. 1995. Chromium(VI)-induced nuclear factor-KB activation in intact cells via free radical reactions. Carcinogenesis 16(10) 2401-2405. 

T. Blackwell, T. Blackwell, E. Holden, B. Christman and J. Christman, In Vivo Antioxidant Treatment Suppresses Nuclear Factor-kB Activation and Neutrophilic Lung Inflammation, J Immunol 157 (1996) 1630-1637. 

G. Rangan, Y. Wang, Y. Tay and D. Harris, Inhibition on Nuclear Factor-KB Activation Reduces Cortical Tubulointestinal Injury in Proteinuric Rats, Kidney Inter 56 (1999) 118-134. 

Arnalich F, Garcia-Palomero E, Lopez J, et al. Predictive value of nuclear factor kb activity and plasma cytokine levels in patients with sepsis. Infect Immunity 2000 68 1942-5. 

Bayon Y, Alonso A, Crespo MS. 4-Trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitor of nuclear factor kB activation. Br J Pharmacol 1999 126 1359-1466. 

Sancho, R, Calzado, M.A., Di Marzo, V., Appendino, G., Munoz, E., 2003. Anandamide inhibits nuclear factor-kB activation through a cannabinoid receptor-independent pathway. Mol. Pharmacol. 63, 429-438. 

Niwa M, Kara A, Kanamori Y, Hatakeyama D, Saio M, Takami T, Matsuno H, Kozawa O, Uematsu T Nuclear factor-KB activates dual inhibition sites in the regulation of tumor necrosis factor-a-induced neutrophil apoptosis. Eur J Pharmacol 2000 407 211-219. 

Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA Dithiocarbamates as potent inhibitors of nuclear factor kB activation in intact cells. J Exp Med 1992 175 1181-1194. 

Bowie A, O Neill LA. Oxidative stress and nuclear factor-KB activation A reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 2000 59 13-23. 

Shao R, Hu M, Zhou B, Lin S, Chiao P, von Lindern R, Spohn B, Hung M (1999) El A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkB kinases and nuclear factor kB activities. J Biol Chem 274 21495-21498... 

Schoonbroodt, S., and J. Piette. 2000. Oxidative stress interference with the nuclear factor-Kb activation pathways. Biochemical Pharmacology 60 1075-83. 

Palmitic acid roles in NAFLD installation and development have been discussed. PA overloading is known to induce apoptotic cell death and a large number of molecular mechanisms have been implicated in this action nitric oxide (NO) synthesis, suppression of antiapoptotic factors such as Bcl-2 [163, 164] reactive oxygen species generation, endoplasmic reticulum stress [165], nuclear factor-kB activation [166],... 

Jove, M Planavila, A Laguna, JC Vazquez-Carrera M. Palmitateinduced interleukin 6 production is mediated by protein kinase C and nuclear-factor kB activation and leads to glucose transporter down-regulation in skeletal muscle eells. Endocrinol, 2005 146 3087-95. 

Coll T, Jove M, Rodriguez-Calvo R, et al. Pahnitate-mediated dowm-egulation of peroxisome proliferator-activated receptor-g coactivator la in skeletal muscle cells involves MEKl/2 and nuclear factor-kB activation. Diabetes. 2006,55 2779-87. 

Perivascular and intra-arterial administration of neutral sphingomyelinase or exogenous short-chain ceramide resulted in a potent concentration-dependent constriction of cortical venules, followed by increased venular waU permeability, post-capillary venule rupture and micro-hemorrhaging (Altura et al, 2002). Treatment with antioxidants, calcium channel blockers and inhibitors of nuclear factor-KB activation could attenuate the effects of neutral sphingomyelinase and ceramide. These results suggest that ceramide can play a role in vasoconstriction and may be involved in the mechanisms resulting in brain injury and stroke. 

Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-KB activation and neutrophilic lung inflammation. J Immunol 1996 157 1630-1637. 

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