NF-kB, Nuclear factor kappa

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... 

The expression of genes involved in cell proliferation and cell death is regulated by nuclear transcriptional factors. NFAT (Nuclear Factor of Activated T cells) proteins are a family of Ca2+-dependent transcription factors (Crabtree, 2001), whose nuclear translocation and transcriptional activity is regulated by Ca2+/calmodulin-dependent protein phosphatase, calcineurin (Crabtree, 2001). Thus, NFAT proteins can potentially be activated by diverse stimuli that lead to increased intracellular calcium levels. The NF-kB (nuclear factor kappa B) family... 

NF-kB nuclear factor kappa B PRRs pattern recognition receptor... 

NF-kB (nuclear factor kappa-light-chain-enhancer of activated B-cells) is a protein complex that acts as a transcription factor. It is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, UV radiation, oxidised lipoproteins and bacterial or viral antigens. It plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-/cB has been linked to cancer, inflammatory and automunune disease, septic shock, viral infection and improper immune development. 

Abbreviations AA arachidonic acid AFA alpha-linolenic acid AP-1 activator protein 1 COX cyclooxygenase DFIA docosahexaenoic acid EPA eicosapentaenoic acid IF interleukin FA linoleic acid FOX lipoxygenase EPS lipopolysaccaride FT leukotriene NF-kB nuclear factor-kappa B, PG prostaglandin PPARs peroxisome proliferator-activated receptors PUFA polyunsaturated fatty acids, RvEl resolvin El, TNFa tumor necrosis factor alpha, TX thromboxane... 

NF-kB nuclear factor kappa-Ught-chain-enhancer of activated... 

NF-kB Nuclear factor kappa-light-chain-enhancer of activated B cells... 

GRAS generally recognized as safe, PGE2 prostaglandin E2, TNF tumor necrosis factor, IL interleukin, NF-kB nuclear factor kappa-light-chain-enhancer of aetivated B cells... 

N. F. National Formulary NF-KB. Nuclear factor kappa B NO. Nitric oxide... 

NF-kB (nuclear factor-kappa B) is a transcription factor so named because its first identified binding site is located within an enhancer in the Ig k light chain gene in mature B cells. The functional NF-kB is a homo- or heterodimer of homologous proteins that share a common structure motif called the Rel domain. The Rel family in the vertebrate includes five cellular proteins p50 (NF-kB 1), p52 (NF-kB2), p65 (RelA), RelB, and c-Rel. The most common NF-kB consists of a p65 p50 heterodimer, but there exists a variety of homodimers and heterdimers, each of which activates its own characteristic set of genes. 

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